EVALUATION OF ANTIEPILEPTIC ACTIVITY OF CASSIA AURICULATA FLOWER EXTRACTS IN MICE
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Keywords
Epilepsy, Cassia auriculata, Anticonvulsant, MES, PTZ, Strychnine, Dopamine, Noradrenaline
Abstract
Objective: To evaluate the antiepileptic activity and estimate brain biogenic amines in mice treated with ethanolic extracts of Cassia auriculata flowers (EECA).
Methods: Anticonvulsant activities of EECA were assessed using Maximal Electroshock Seizure (MES), Pentylenetetrazole (PTZ), and Strychnine-induced seizure models in mice. Biogenic amine levels were estimated via HPLC.
Results: EECA significantly reduced tonic hind limb extension in the MES model and delayed seizure onset in PTZ and Strychnine models. Brain dopamine and noradrenaline levels increased post-EECA treatment. Motor coordination tests indicated mild impairment at anticonvulsant doses.
Conclusion: EECA demonstrates dose-dependent antiepileptic activity, likely due to flavonoids and antioxidant phytoconstituents.
References
2. Epileptic Seizures and Epilepsy: Definitions Proposed by the ILAE and IBE. Epilepsia. 2005;46(4):470–2. https://doi.org/10.1111/j.0013-9580.2005.66104.x
3. Mayo Clinic. Epilepsy overview. https://www.mayoclinic.org/diseases-conditions/epilepsy /symptoms-causes/syc-20350093
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Ramchandra Pudasaini
"Aditya Institute of Pharmacy Education and Research, Bangalore, Karnataka"