EVALUATION OF HLA-B27 ANTIGEN IN SERONEGATIVEGROUP OF ARTHRITIS IN A TERTIARY CARE HOSPITAL INTHE STATE OF WEST BENGAL
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Keywords
rheumatoid arthritis, arthropathy, HLA B27 gene, RTPCR, HLA-B27 antigen, seronegative arthritis, Sacroilitis
Abstract
Introduction- Seronegative group of arthritis is a common arthropathy in Indian population ,second only to rheumatoid arthritis. HLA B27 has been seen to be strongly associated with this group of arthropathy. The major aim of this project is to asses the distribution of HLA B27 gene in our study population and its distribution along various other parameters.
Materials and methods- The various methods includes blood collection of the patient followed by DNA extraction and amplification by RTPCR and finally analysis of HLA-B27 antigen. Thereby, the necessary findings are reported and recorded accordingly .
Results and conclusion - HLA B27 gene was found to be present in 77.6% individuals presenting with seronegative arthritis. Out of all the patients who were found positive for HLA B27, majority were males (71%) and mainly distributed in the age group of 16-50years. An Acute red eye was found as the most common articular manifestation in these patients were as cervical pain was found to be the most common articular manifestation in addition to lower back pain. Sacroilitis was the most found MRI impression in these patients. Considering the variable distribution of the disease and various presentations, it becomes even more important to define its associations , so as to allow a better room for choosing treatment plans and change the prognosis of the disease.
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Dr Anirrudha Mondal
Assistant professor, Dept of Orthopaedics, NRSMCH, MBBS, DMRT Radiotherapy, DNB Ortho, +91 81006 35427
Dr. Shreyans Agrawal
Post Graduate Trainee, Dept of Orthopaedics NRSMCH, MBBS (Hons.), MRCS (Edinburgh), MS (Orthopaedics)
Dr Satyaki Dandi
Senior Resident , Dept of Orthopaedics NRSMCH, MBBS, MS Ortho, DNB Ortho
Dr. Arumoy Bhuimali
Assistant Professor, Dept of Orthopaedics, NRSMCH, MBBS (Hons.), MS (Orthopaedics)
Dr. Sanjay Saha
Senior Resident, Dept of Orthopedics, NRSMCH, MBBS (Hons.), MS (Orthopaedics)