EFFICACY OF TRANSDERMAL KETOPROFEN PATCH VS DICLOFENAC PATCH IN LAPAROSCOPIC CHOLECYSTECTOMY: A RANDOMIZED CONTROLLED TRIAL
Main Article Content
Keywords
Transdermal ketoprofen patch, acute post operative pain, adverse effects, laparoscopic cholecystectomy
Abstract
Background: Pain which occurs due to tissue damage modulates the somatosensory system, which increases the responsiveness of central and peripheral pain pathways. All methods of post operative pain analgesia must meet three basic criteria, it must be safe, effective and predictable.2 Objective: to compare the effectiveness of a transdermal ketoprofen patch combined with a diclofenac patch in patients undergoing general anaesthesia during laparoscopic cholecystectomy Methods: Randomized controlled study was conducted at Department of Anaesthesiology, Rohilkhand Medical College and Hospital, Bareilly, UP. Total 76 patients were taken in the study which were divided into two groups, 38 patients in each group. In group 1, patients were given a transdermal patch containing ketoprofen and in group 2, patients were given a transdermal patch containing sodium diclofenac. 10-point Visual Analogue Scale (VAS) at immediate post operative, 2, 4, 6, 12 and 24 hours, Time to first rescue analgesia, Effectiveness of pain treatment in first 24 hours using APS-POQ-R, Haemodynamic changes adverse effects of patch were assessed. Result: The demographic profile was similar in both the groups Haemodynamic changes. There was no significant variation among both the groups in terms of these parameters. More VAS in diclofenac group as compared to ketoprofen group. VAS score was insignificant at 12 and 24 hour postoperatively. There was no difference significantly among the two groups in the time taken to first rescue analgesia. APS-POQ-R. assesses six aspects of quality: as pain intensity and relief, Impact of pain on activity and sleep, negative emotions, usefulness of information about pain treatment, the capacity to take part in decisions regarding pain management, usefulness of information about pain treatment and assessment of therapy side effects and patient satisfaction with pain management. Compared to the diclofenac group, the ketoprofen group experienced lower levels of pain severity, Both groups saw fewer side effects, which were not statistically significant
Conclusion: Transdermal ketoprofen patch is effective and safe in management of acute post operative pain with better pain relief, longer duration of action, better in reducing the severity of pain in post operative period and lesser adverse effects in laparoscopic cholecystectomy
References
2. Bachalli PS, HN, NS. A comparative study of diclofenac transdermal patch against oral diclofenac patch for pain control following removal of mandibular impacted third molars. J Maxillofac Oral Surg.2009;8(2):167-72.
3. Pandey K, Shettar V, Kale T. Efficacy of Transdermal Ketoprofen Patch in Comparison to Transdermal Diclofenac Patch in Postoperative Analgesia for Orthodontic Extractions: A Randomized Split-Mouth Study. Cureus.2023;15(4)1- 11.
4. Gordon DB, Polomano RC, Pellino TA, Turk DC, McCracken LM, Sherwood G et al. Revised American Pain Society Patient Outcome Questionnaire (APS-POQ-R) for Quality Improvement of Pain Management in Hospitalized Adults: Preliminary Psychometric Evaluation. The Journal of Pain.2010;11(11):1172-86.
5. Verma R, Kumar S, Goyal A, Chaudhary A. Comparison of single dose transdermal patches of diclofenac and ketoprofen for postoperative analgesia in lower limb orthopaedic surgery. International Journal of Research in Medical Sciences.2016;4(3):718-21.
6. Jadhav P, Sinha R, Uppada UK, Tiwari PK, Kumar AVSSS. J. Maxillofac. Oral Surg.2018;17(4):488-94.
7. Kabir KK, Banjare M, Sharma N, Arora KK. Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as pre-emptive analgesia in patients undergoing inguinal hernia surgeries. International Journal of Medical Anesthesiology.2020;3(3):28-31.
8. Shankar D, Sinha A, Anand S, Verma N, Choudhary S. Efficacy of Transdermal Diclofenac Patch and Ketoprofen Patch as Postoperative Analgesia after Extraction of First Premolars Bilaterally in Both Arches for Orthodontic Purpose: A comparative Study. J Pharm Bioallied Sci.2021;13(1):101-4.
9. Bhargav D, Thomas S, Beena S. Comparison Between Efficacy of Transdermal Ketoprofen and Diclofenac Patch in Patients Undergoing Therapeutic Extraction – A Randomized Prospective Split Mouth Study. Journal of Oral and Maxillofacial Surgery.2019;77(10):1998-2003.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Swarna Rajhans
Junior Resident, Department of Anaesthesiology Rohilkhand Medical College & Hospital, Bareilly U.P India
Neeharika Arora
Professor, Professor & Head, Department of Anesthesiology, Rohilkhand Medical College & Hospital, Bareilly, U.P India
Divya Vijay
Assistant Professor, Department of Anesthesiology, SRMS Bareilly, U.P India
Jyoti Pathania
Professor & Head, Department of Anesthesiology, Rohilkhand Medical College & Hospital, Bareilly, U.P India