OCULAR MANIFESTATIONS IN HEMATOLOGICAL MALIGNANCIES: AN OBSERVATIONAL STUDY IN A MEDICAL COLLEGE & CANCER HOSPITAL IN WEST BENGAL
Main Article Content
Keywords
Hematological malignancies, Intra retinal Haemorrhages, sub conjunctival haemorrhages, fundus examination.
Abstract
Background: Haematological malignancies like Leukemia, Lymphoma & Myeloma can cause ocular manifestations which can be vision threatening sometimes. This study aims to evaluate the ocular manifestations in haematological malignancies in a medical college & cancer hospital in West Bengal.
Methods: In this hospital based cross sectional study conducted in the Department of Ophthalmology of Sri Ramkrishna Institute of Medical Sciences & Sanaka cancer Hospital in Durgapur, West Bengal, we examined total of 121 patients having hematological malignancies in between July 2023 to June 2024.
Results: Among 121 patients ocular manifestations were noted in 59 patients.Most common Anterior segment finding was subconjunctival haemorrhage (5.08%), whereas most common posterior segment manifestation was intra retinal haemorrhage. Vision threatening complications like sub hyaloid haemorrhage, exudative RD & mcular edema were noted in 19 patients.
Conclusions: Ocular involvement specially retinal involvement is common in hematological malignancies.So ocular examination specially fundus examination should be done in each & every patient of hematological malignancies.
Methods: In this hospital based cross sectional study conducted in the Department of Ophthalmology of Sri Ramkrishna Institute of Medical Sciences & Sanaka cancer Hospital in Durgapur, West Bengal, we examined total of 121 patients having hematological malignancies in between July 2023 to June 2024.
Results: Among 121 patients ocular manifestations were noted in 59 patients.Most common Anterior segment finding was subconjunctival haemorrhage (5.08%), whereas most common posterior segment manifestation was intra retinal haemorrhage. Vision threatening complications like sub hyaloid haemorrhage, exudative RD & mcular edema were noted in 19 patients.
Conclusions: Ocular involvement specially retinal involvement is common in hematological malignancies.So ocular examination specially fundus examination should be done in each & every patient of hematological malignancies.
References
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[2] Reddy SC, Jackson N, Menon BS. Ocular involvement in leukemia A study of 288 cases. Ophthalmologica 2003;217:441 5.
[3] Orhan B, Malbora B, Akça Bayar S, Avcı Z, Alioğlu B, Özbek N. Ophthalmologic findings in children with leukemia: A single center study. Turk J Ophthalmol 2016;46:62 7.
[4] Omoti AE, Omoti CE. Ophthalmic manifestations of multiple myeloma. West Afr J Med 2007;26:265 8.
[5] Singh AD. The prevalence of ocular disease in chronic lymphocytic leukemia. Eye (Lond) 2003;17:3 4.
[6] Sharma T, Grewal J, Gupta S, Murray PI. Ophthalmic manifestations of acute leukaemias: The ophthalmologist’s role. Eye (Lond) 2004;18:663 72.
[7] Bahakeem E, Qadah T. Current diagnostic methods for hematological malignancies: a mini review. Pharmacophore 2020;11:63 8.
[8] Ilo OT, Adenekan AO, Alabi AS, Onakoya AO, Aribaba OT, Kehinde MO, et al. Ocular manifestations of leukaemia: a teaching hospital experience. Niger Postgrad Med J 2019;26:205 10.
[9] Dhasmana R, Prakash A, Gupta N, Verma SK. Ocular manifestations in leukemia and myeloproliferative disorders and their association with hematological parameters. Ann Afr Med 2016;15:97 103.
[10] Omoti AE, Omoti CE, Momoh RO. Ophthalmic disorders in adult lymphoma patients in Africa. Middle East Afr J Ophthalmol 2009;16:252 5.
[11] Menon LM, John E, Deepthi R, Shaji A. Prevalence of ocular manifestation in haematological malignancies A clinical study. IOSR J Dent Med Sci 2018;17:22 8.
[12] Eze BI, Ibegbulam GO, Ocheni S. Ophthalmic manifestations of leukemia in a tertiary hospital population of adult nigerianafricans. Middle East Afr J Ophthalmol 2010;17:325 9.
[13] Bukhari ZM, Alzahrani A, Alqarni MS, Alajmi RS, Alzahrani A, Almarzouki H, et al. Ophthalmic manifestations in acute leukemia patients and their relation with hematological parameters in a tertiary care center. Cureus 2021;13:e19384.
[14] Koshy J, John MJ, Thomas S, Kaur G, Batra N, Xavier WJ. Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India. Indian J Ophthalmol 2015;63:659 64.
[15] Chin KJ, Kempin S, Milman T, Finger PT. Ocular manifestations of multiple myeloma: Three cases and a review of the literature. Optometry 2011;82:224 30.
[16] Soman S, Kasturi N, Srinivasan R, Vinod KV. Ocular manifestations in leukemias and their correlation with hematologic parameters at a tertiary care setting in South India. Ophthalmol Retina 2018;2:17-23
[17] Suresh K, Sampath R, Tanvi. Ocular manifestations in hematological disorders. SRMC 2011;4:1 4.
[18] Bouazza M, Youssefi H, Bouanani N. Ocular manifestations in hematological disorders. Cureus 2022;14:e27941.
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Published
Apr 01, 2025
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Dr. Parthapratim Mandal, Dr. Raghudev Bhattacharjee, & Dr. Sumitavo Ghosh. (2025). OCULAR MANIFESTATIONS IN HEMATOLOGICAL MALIGNANCIES: AN OBSERVATIONAL STUDY IN A MEDICAL COLLEGE & CANCER HOSPITAL IN WEST BENGAL. Journal of Population Therapeutics and Clinical Pharmacology, 32(3), 05-10. https://doi.org/10.53555/0np64j80
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Author Biographies
Dr. Parthapratim Mandal
Associate Professor, Department of Ophthalmology, Sri Ramkrishna Institute of Medical Science & Sanaka Hospital, Durgapur, Burdwan, West Bengal, India.
Dr. Raghudev Bhattacharjee
Assistant Professor, Department of Ophthalmology, Sri Ramkrishna Institute of Medical Science & Sanaka Hospital, Durgapur, Burdwan, West Bengal, India.
Dr. Sumitavo Ghosh
Assistant Professor, Department of Radiation Oncology, Sri Ramkrishna Institute of Medical Science & Sanaka Hospital, Durgapur, Burdwan, West Bengal, India.
How to Cite
Dr. Parthapratim Mandal, Dr. Raghudev Bhattacharjee, & Dr. Sumitavo Ghosh. (2025). OCULAR MANIFESTATIONS IN HEMATOLOGICAL MALIGNANCIES: AN OBSERVATIONAL STUDY IN A MEDICAL COLLEGE & CANCER HOSPITAL IN WEST BENGAL. Journal of Population Therapeutics and Clinical Pharmacology, 32(3), 05-10. https://doi.org/10.53555/0np64j80