HELICOBACTER PYLORI INFECTION: AS A RISK FACTOR FOR ANEMIA, A PHYSIOLOGICAL PERSPECTIVE FROM SHAHEED BENAZIRABAD
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Keywords
Helicobacter Pylori, MCV, RDW, Red blood cell morphology
Abstract
Background: Helicobacter pylori infection is a very common entity these days in children and adults irrespective of the gender and religion and its impact on health is quite disturbing. The current study was planned and executed to evaluate the impact of H. Pylori infection on the hemoglobin levels and RBCs morphology and indexes.
Methods: This case control study, carried out in the outpatient department of the People Medical College Hospital, Nawabshah, Sindh, Pakistan over 06 months. There were 384 study participants, 192 helicobacter pylori +ve patients and 192 healthy individuals as controls. Patients were randomly selected with an age ranging10 years to 60 years. Blood samples taken under aseptic measures were analyzed for hematological evaluations.
Results: The mean age was 37.21+5.11 years in H-pylori infected individuals (Group-A) while it was 33.11+4.51 years in controls(Group-B). There were 168 males and 216 females among the study participants. A significant difference was observed in RBC count among the two groups, 3.1±1.0 x 106million/mm3 and 4.8±1.9 x 106million/mm3 in Group-A and Group-B respectively (p-0.03). Similarly significant difference was observed in MCV for the two study groups which was 71.04±7.1fl and 84.13±6.8 fl for Group-A and Group-B respectively (0.001). Significant statistical difference was found in MCH and RDW among the two groups.
Conclusion: H. Pylori infection significantly affects RBCs count and morphology which may lead to microcytic and hypochromic anemia in patients suffering from this infection.
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Ghulam Muhammad Phull
MBBS Assistant Professor Department of Physiology Gambat Medical College Gambat, Khairpur Mirs, Sindh, Pakistan
Altaf Hussain Memon
MBBS Associate Professor, Department of Physiology People University of Medical and Health Sciences for Women Nawabshah, Sindh, Pakistan
Bhojo Mal Tanwani
MBBS Associate Professor, Department of Physiology People University of Medical and Health Sciences for Women Nawabshah, Sindh, Pakistan
Altaf Khan Pathan
MBBS Associate Professor, Department of Physiology People University of Medical and Health Sciences for Women Nawabshah, Sindh, Pakistan
Masood Nabi Noor Dhahri
MBBS Associate Professor, Department of Physiology People University of Medical and Health Sciences for Women Nawabshah, Sindh, Pakistan
Sikander Ali Bhand
MBBS, FCPS (Pediatrics) Associate Professor Department of Pediatrics Liaquat Institute of Medical and Health Sciences Thatta