ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA FROM VARIOUS CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL OF RAJASTHAN
Main Article Content
Keywords
Pseudomonas aeruginosa, antimicrobial resistance, hospital-acquired infections, multidrug resistance
Abstract
Introduction
Pseudomonas aeruginosa is a gram-negative, opportunistic pathogen commonly associated with hospital-acquired infections. Due to its intrinsic and acquired resistance mechanisms, it poses significant treatment challenges. Aim and objectives: This study examines the prevalence and antimicrobial susceptibility pattern of P. aeruginosa isolated from various clinical samples in a tertiary care hospital in Rajasthan. Result: A total of 114 isolates were analyzed, revealing a higher prevalence in males (76%) and individuals aged 60-70 years (22%). Blood samples were the most common source (45%), followed by sputum (19%) and body fluids (15%). The most effective antibiotics were Colistin (97%), Tobramycin (87%), and Cefepime (84%), whereas resistance was highest against Tigecycline (71%), Minocycline (68%), and Imipenem (54%).Conclusion: These findings emphasize the need for routine antimicrobial susceptibility testing to guide appropriate treatment and mitigate the spread of multidrug-resistant (MDR) strains.
References
2) Engel, J., & Balachandran, P. (2009). Role of Pseudomonas aeruginosa type III effectors in disease. Elsevier, 12(1), 61-66.
3) Høiby, N., Bjarnsholt, T., Givskov, M., Molin, S., & Ciofu, O. (2010). Antibiotic resistance of bacterial biofilms. International Journal of Antimicrobial Agents, 35(4), 322-332.
4) Koneman, E. W., Allen, S. D., Janda, W. M., Schreckenberger, P. C., & Winn, W. C. (2006). Diagnostic microbiology (6th ed.). Philadelphia: Lippincott Williams & Wilkins.
5) Livermore, D. M. (2002). Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare? Clinical Infectious Diseases, 34(5), 634–640.
6) Negi, S., Ramanath, K., Bala, L., & Sharma, M. K. (2021). Antibiotic susceptibility patterns of Pseudomonas sp. Isolated from various clinical samples at a tertiary care hospital at Dewas in Madhya Pradesh, India. Indian Journal of Microbiology Research, 8(1), 65-70.
7) Stover, C. K., Pham, X. Q., Erwin, A. L., et al. (2000). Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature, 406, 959–964.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Biraj Louriyam
Msc, Medical Microbiology Department of Microbiology, National Institute of Medical Sciences and Research, Jaipur (India)
Dr. Ankit Pradhan
Professor & Head, Department of Microbiology, National Institute of Medical Sciences and Research, Jaipur (India)
Dr. Rakesh K Maheshwari
Professor & Head, Department of Microbiology, National Institute of Medical Sciences and Research, Jaipur (India)