ASSESSMENT OF PROTEIN S LEVELS IN YOUNG PATIENTS (20-45YEARS) WITH MYOCARDIAL INFARCTION REPORTING TO SHAIKH ZAYED HOSPITAL LAHORE
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Keywords
Protein S Deficiency, Myocardial Infarction, Young Patients
Abstract
Background: Free protein S is a physiological inhibitor of coagulation. In many studies involving, especially young subjects, decreased fibrinolysis has been observed to be related to a high risk of intravascular arterial thrombosis. This study was planned to assess young patient’s thrombotic risk potential for myocardial ischemia and infarction and preventive measures can be taken well in time in young patients with protein S deficiency.
Objective: To determine the proportion of protein S deficiency in young patients diagnosed with myocardial infarction (age 20 to 45 years).
Methodology: This descriptive observational study was carried out at the Department of Haematology, Shaikh Zayed Medical Complex, Lahore. The duration of the study was one year after approval of the synopsis. After meeting inclusion and exclusion criteria, 75 patients with myocardial infarction were enrolled. Informed consent and demographic details were taken. Venous blood samples were taken and stored in a blue top vacuum tube. If protein S levels were less than 70 U/dL, then protein S deficiency was labeled.
Results: In our study among myocardial infarction patients the protein S deficiency was noted in 21(28%) patients. In diabetic patients, protein S deficiency was noted in 18 (36.7%) patients, and in non-diabetic patients, it was noted in 3 (11.5%) patients (p-value = 0.021).Among smokers, protein S deficiency was noted in 13 (44.8%) patients and in non-smokers, it was noted in 8 (17.4%) patients (p-value = 0.010) and in patients with a family history of MI, protein S deficiency was noted in 20 (55.6%) patients and in patients without a family history of MI, it was noted in 1 (2.6%).
Conclusion: The proportion of protein S deficiency in young patients diagnosed with myocardial infarction (age 20 to 45 years) is 28%, whereas factors like diabetes mellitus, smoking status, and family history of MI are associated with protein S deficiency in the patients.
References
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Ahmed Latif Chaudhary
Medical Officer, Department of Pathology, Children’s Hospital and University of Child Health Sciences, Lahore, Pakistan
Sameen Hassan
Demonstrator, Department of Pathology, Sharif Medical & Dental College and Hospital, Lahore, Pakistan
Attia Lateef
Assistant Professor Department of Pathology, Sharif Medical & Dental College and Hospital, Lahore, Pakistan
Saleha Maqsood
Demonstrator, Department of Pathology, Sharif Medical & Dental College and Hospital, Lahore, Pakistan
Naveen Bilal
Demonstrator, Department of Pathology, Sharif Medical & Dental College and Hospital, Lahore, Pakistan
Nazish Jamil
Assistant Professor Department of Physiology, Sharif Medical & Dental College and Hospital, Lahore, Pakistan