IMPACT OF SMOKING ON SKIN AGING AND DERMATOLOGICAL DISORDERS: A META-ANALYSIS
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Keywords
Impact of Smoking, Skin Aging, Dermatological Disorders, Meta-Analysis
Abstract
This meta-analysis explores how smoking affects skin ageing and skin diseases by combining results from 15 studies conducted from 2005 to 2023. Smoking has been proven to exacerbate skin ageing changes, such as the formation of wrinkles, skin loosening, and changes in skin quality. Furthermore, smoking is believed to have a stronger correlation with specific subsequences of dermatological conditions like psoriasis, acne, eczema, and skin cancers, particularly squamous and basal cell carcinoma. The biological reasons for these changes include oxidative skin damage, hypoxia, and collagen scar formation, which causes early skin ageing and deteriorated skin health. Subgroup analyses showed that the intensity, duration, and age at which an individual started smoking, as well as their gender and skin type, showed worsening symptoms of skin damage. The detrimental effects of smoking were particularly severe among women and members of the high-risk skin type genetic group. The meta-analysis further showed that stopping smoking was one of the most effective ways of reducing skin ageing and improving skin conditions. Based on the results of this study, it is recommended that healthcare practitioners, especially those working as dermatologists, should regularly inquire about their patient’s smoking status and actively encourage cessation within their management plans.
Additional investigations should be aimed at delineating the chronic impacts of smoking cessation relative to skin healing, as well as further exploring the biological mechanisms of smoking-related skin problems.
This abstract attempts to encapsulate the most relevant aspects of the meta-analysis and its consequences for clinical and public health practice.
References
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2019). Neuroendocrine aspects of skin aging. International journal of molecular sciences, 20(11), 2798.
Bostrom, N., & Yudkowsky, E. (2018). The ethics of artificial intelligence. In Artificial intelligence safety and security (pp. 57-69). Chapman and Hall/CRC.
Bravo, B., Correia, P., Gonçalves Junior, J. E., Sant'Anna, B., & Kerob, D. (2022). Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatologic therapy, 35(12), e15903.
Carr, A. C., & Rowe, S. (2020). Factors affecting vitamin C status and prevalence of deficiency: A global health perspective. Nutrients, 12(7), 1963.
Chiou, W. L. (2024). Advancing New Views on the Causes and Prevention of Skin Cancer and Aging of the Skin. Medical Research Archives, 12(4).
Clements, C. (2023). Skin Hydration, Injury Prevalence and Frequency: Understanding the Influence of Physiologic, Behavioral and Demographic Factors (Doctoral dissertation, University of Pennsylvania).
Datta, D., Sultana, S., Strauss, J., Puri, A., Bandi, S. P., & Singh, S. (2024). Reconnoitring signaling pathways and exploiting innovative approaches tailoring multifaceted therapies for skin cancer. International Journal of Pharmaceutics, 124719.
Dorf, N., & Maciejczyk, M. (2024). Skin senescence—from basic research to clinical practice. Frontiers in Medicine, 11, 1484345.
Eidt, L. M. (2023). Cutaneous Aging and Dermatosis in Geriatric Patients. In Dermatology in public health environments: a comprehensive textbook (pp. 967-1001). Cham: Springer International Publishing.
Ferreira, I. M. D. C. (2023). Instruments used to characterize skin type and skin aging: a scoping review.
Fitzgerald, R., Carqueville, J., & Yang, P. T. (2019). An approach to structural facial rejuvenation with fillers in women. International Journal of Women’s Dermatology, 5(1), 52-67.
Fleckenstein, M., Keenan, T. D., Guymer, R. H., Chakravarthy, U., Schmitz-Valckenberg, S., Klaver, C. C., ... & Chew, E. Y. (2021). Age-related macular degeneration. Nature reviews Disease primers, 7(1), 31.
Goodman, G. D., Kaufman, J., Day, D., Weiss, R., Kawata, A. K., Garcia, J. K., ... & Gallagher, C. J. (2019). Impact of smoking and alcohol use on facial aging in women: results of a large multinational, multiracial, cross-sectional survey. The Journal of clinical and aesthetic dermatology, 12(8), 28.
Hussein, R. S., Bin Dayel, S., Abahussein, O., & El‐Sherbiny, A. A. (2024). Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. Journal of Cosmetic Dermatology, e16688.
Kakaraparthi, V., Shao, Q., Carver, C. J., Pham, T., Bui, N., Nguyen, P., ... & Vu, T. (2021). FaceSense: sensing face touch with an ear-worn system. Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies, 5(3), 1-27.
Lee, H., Hong, Y., & Kim, M. (2021). Structural and functional changes and possible molecular mechanisms in aged skin. International journal of molecular sciences, 22(22), 12489.
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023). Inflammation and aging: signaling pathways and intervention therapies. Signal Transduction and Targeted Therapy, 8(1), 239.
Liang, Y., Su, W., & Wang, F. (2023). Skin ageing: a progressive, multi-factorial condition demanding an integrated, multilayer-targeted remedy. Clinical, cosmetic and investigational dermatology, 1215-1229.
Limbert, G., Masen, M. A., Pond, D., Graham, H. K., Sherratt, M. J., Jobanputra, R., & McBride, A. (2019). Biotribology of the ageing skin—Why we should care. Biotribology, 17, 75-90.
Liu, W., Krutmann, J., Tian, Y., Granger, C., Piquero-Casals, J., Trullàs, C., ... & Lai, W. (2023). Commentary: facial aesthetic dermatological procedures and Photoprotection in Chinese populations. Dermatology and Therapy, 13(1), 13-27.
Mahamat-Saleh, Y., Cervenka, I., Al Rahmoun, M., Savoye, I., Mancini, F. R., Trichopoulou, A., ... & Kvaskoff, M. (2019). Mediterranean dietary pattern and skin cancer risk: a prospective cohort study in French women. The American journal of clinical nutrition, 110(4), 993-1002.
Mohiuddin, A. K. (2019). Skin aging & modern age anti-aging strategies. Int. J. Clin. Dermatol. Res, 7, 209-240.
Muthukrishnan, A., & Warnakulasuriya, S. (2018). Oral health consequences of smokeless tobacco use. Indian Journal of Medical Research, 148(1), 35-40.
Niles, A. N., & O’Donovan, A. (2019). Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms. Health Psychology, 38(2), 172.
Perricone, C., Versini, M., Ben-Ami, D., Gertel, S., Watad, A., Segel, M. J., ... & Shoenfeld, Y. (2019). Smoke and Autoimmunity: The Fire Behind the Disease. In Mosaic of Autoimmunity (pp. 383-415). Academic Press.
Pesqué, D., Aerts, O., Bizjak, M., Gonçalo, M., Dugonik, A., Simon, D., ... & Giménez‐Arnau, A. M. (2024). Differential diagnosis of contact dermatitis: A practical‐approach review by the EADV Task Force on contact dermatitis. Journal of the European Academy of Dermatology and Venereology.
Ramo, D. E., Meacham, M., Thrul, J., Belohlavek, A., Sarkar, U., & Humfleet, G. (2019). Exploring identities and preferences for intervention among LGBTQ+ young adult smokers through online focus groups. Journal of Adolescent Health, 64(3), 390-397.
Roszkiewicz, M., Dopytalska, K., Szymanska, E., Jakimiuk, A., & Walecka, I. (2020). Environmental risk factors and epigenetic alternations in psoriasis. Annals of Agricultural and Environmental Medicine, 27(3).
Schneeweiss, S., & Suissa, S. (2019). Advanced approaches to controlling confounding in pharmacoepidemiologic studies. Pharmacoepidemiology, 1078-1107.
Sondermeijer, L., Lamboo, L. G., de Waal, A. C., Galesloot, T. E., Kiemeney, L. A., van Rossum, M., & Aben, K. H. (2020). Cigarette smoking and the risk of cutaneous melanoma: a case-control study. Dermatology, 236(3), 228-236.
Venkatesh, S., Maymone, M. B., & Vashi, N. A. (2019). Aging in skin of color. Clinics in dermatology, 37(4), 351-357.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Rodha Saeed Al Musallam
Dubai Health, 0009-0003-5479-2330,
Nazly Ibech
University of Sharjah,
Maram Al-Salman
Zulekha hospital Dubai,
Reem Sultan Bin Tarish Al Mheiri
University of Sharjah, College of Medicine,
Saara Ansar Ahmed
RAK Medical & Health Sciences University
Noora Al Ali
MBRU, 0009-0000-7739-5627,
Meera al Shirawi
MBRU, 0009-0000-1466-0921,
Shaikha Mohammed M ALQahtani
Rashid Hospital, 0009-0000-1920-2129,
Maria Zuhair Alsannaa
RCSI, 0009-0007-4771-3349,
Sara Ahmed Al Amoodi
Gulf medical university, College of Medicine,