EVALUATION OF MAST CELL DENSITY IN TISSUES OF LEPROSY & ITS COMPARISON WITH CLINIC-PATHOLOGICAL PARAMETERS
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Keywords
inflammation, leprosy, mast cell, mycobacterium leprae, reaction type
Abstract
Background: Leprosy, sometimes referred to as Hansen's disease (HD), is a persistent infection caused by Mycobacterium leprae. Mast cells in leprosy have been recently studied & are under consideration for future research. the present study was done to assess Mast Cell Density in tissues of leprosy & compare with clinic-pathological parameters.
Methods: The retrospective study was conducted at Hi Tech Medical College, among 100 cases of skin leprosy patients during the study period of one year. The mean quantity of mast cells per high power field was determined.
Results: The mean age of patients was 43.5±3.8 years. Out of 100 cases; 76% were male & 24% were female. The most common type of leprosy seen were paucibacillary (60) & mutibacillary (40). No reaction was found in 64 cases whereas type I reaction was seen 26 cases & type II reaction was seen in 10 cases. The number of mean mast cell found in no reaction was 22.3±10.1, in Type I reaction was 10.4±3.9 & in Type II reaction was 12.7±4.1. The histopathological slides shows most common type was borderline lepromatous in 22% cases & borderline in 20% cases. Significant association (p<0.05) between number of mast cell in each area by leprosy reaction type was seen.
Conclusion: Infiltrating mast cells contribute to lesion progression, as seen by the increased mast cell density in cutaneous leprosy lesions. Border line leprosy with interstitial region had considerably greater MCD. Increased mast cell counts indicate a better disease prognosis in cutaneous leprosy lesions.
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Dr. Madhusmita Mishra
Assistant Professor, Department of Pathology, Hi Tech Medical College and Hospital, Bhubaneswar, Odisha, India.
Dr. Dilip Kumar Das
Assistant Professor, Department of Pathology, Hi Tech Medical College and Hospital, Bhubaneswar, Odisha, India.
Dr. Swagatika Agrawal
Professor, Department of Pathology, IMS and SUM 2 Hospital, Phulnakhara, Bhubaneswar, Odisha, India.