ROLE OF REGENERATIVE MEDICINE IN ORTHOPEDICS OSTEOMYELITIS
Main Article Content
Keywords
Regenerative Medicine, Orthopaedics, Stem Cell Therapy, Platelet-Rich Plasma, Randomized Controlled Trial
Abstract
This study aimed to evaluate the efficacy and safety of regenerative medicine compared to conventional orthopedic treatments in a randomized controlled trial. The research focused on pain reduction, functional improvement, range of motion, and patient satisfaction. Participants were randomly assigned to either the Regenerative Medicine Group, receiving treatments such as stem cell therapy and platelet-rich plasma (PRP) injections, or the Control Group, which received standard orthopedic care. Major findings revealed that the Regenerative Medicine Group experienced significantly greater reductions in pain, improved functional outcomes, enhanced range of motion, and higher patient satisfaction compared to the Control Group. These results suggest that regenerative therapies offer superior benefits over traditional treatments, providing more effective pain management and functional recovery. The study concludes that regenerative medicine has the potential to transform orthopaedic care by addressing both symptoms and underlying conditions more effectively. Future research should focus on long-term outcomes, cost-effectiveness, and optimizing treatment protocols.
References
2. Baiguera, S., Birchall, M.A. and Macchiarini, P. (2010) Tissue-Engineered Tracheal Transplantation. Transplantation, 89, 485-491.
3. Blundell, J. (1818) Experiments on the Transfusion of Blood by the Syringe. Medico-Chirurgical Transactions, 9, 56-92.
4. Daar, A.S. and Greenwood, H.L. (2007) A Proposed Definition of Regenerative Medicine. Journal of Tissue Engineering and Regenerative Medicine, 1, 179-184.
5. Goodarzi, P., et al. (2018) Tissue Engineered Skin Substitutes. Advances in Experimental Medicine and Biology, 1107, 143-188.
6. Hoffman, T., Khademhosseini, A. and Langer, R. (2019) Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering. Tissue Engineering Part A, 25, 679-687.
7. Jacques, E. and Suuronen, E.J. (2020) The Progression of Regenerative Medicine and Its Impact on Therapy Translation. Clinical and Translational Science, 13, 440-450.
8. Kessler, M.W. and Grande, D.A. (2008) Tissue Engineering and Cartilage. Organogenesis, 4, 28-32.
9. Kobayashi, E. and Haga, J. (2016) Translational Microsurgery. A New Platform for Transplantation Research. Acta Cirúrgica Brasileira, 31, 212-217.
10. Macchiarini, P., et al. (2008) Clinical Transplantation of a Tissue-Engineered Airway. The Lancet, 372, 2023-2030.
11. Mason, C. and Dunnill, P. (2008) A Brief Definition of Regenerative Medicine. Regenerative Medicine, 3, 1-5.
12. Murray, J.E., Merrill, J.P. and Harrison, J.H. (1958) Kidney Transplantation between Seven Pairs of Identical Twins. Annals of Surgery, 148, 343-359.
13. Orlando, G., et al. (2011) Regenerative Medicine as Applied to Solid Organ Transplantation: Current Status and Future Challenges. Transplant International, 24, 223-232.
14. Orlando, G., et al. (2011) Regenerative Medicine and Organ Transplantation: Past, Present, and Future. Transplantation, 91, 1310-1317.
15. Plotner, A.N. and Mostow, E.N. (2010) A Review of Bioactive Materials and Chronic Wounds. Cutis, 85, 259-266.
16. Raya-Rivera, A., et al. (2011) Tissue-Engineered Autologous Urethras for Patients Who Need Reconstruction: An Observational Study. The Lancet, 377, 1175-1182.
17. Risbud, M.V. and Sittinger, M. (2002) Tissue Engineering: Advances in in Vitro Cartilage Generation. Trends in Biotechnology, 20, 351-356.
18. Shimmura, S. and Tsubota, K. (2003) Regeneration of the Cornea. Nihon Rinsho, 61, 475-479.
19. Sommer, F., Brandl, F. and Göpferich, A. (2006) Ocular Tissue Engineering. Advances in Experimental Medicine and Biology, 585, 413-429.
20. Sohier, J., et al. (2008) Critical Factors in the Design of Growth Factor Releasing Scaffolds for Cartilage Tissue Engineering. Expert Opinion on Drug Delivery, 5, 543-566.
21. Yang, Z., Xie, H. and Li, T. (2000) Tissue Engineering of the Musculo-Skeletal System—Basic Research and Clinical Applications. Journal of Hand Surgery, 5, 49-55.
22. Jadlowiec, C.C. and Taner, T. (2016) Liver Transplantation: Current Status and Challenges. World Journal of Gastroenterology, 22, 4438-4445.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Gautam Kashyap
Assistant Professor, Department of Orthopedics, CCMGMCH Durg, (C.G)
Dr Deepak Ghritlahre
Assistant Professor, Department of Orthopedics, SBDMS Medical College Korba, (C.G)
Dr Champa Singh Kanwar
Assistant Professor, Department of Orthopedics, SBDMS Medical College Korba, (C.G).