ROLE OF TRANEXAMIC ACID ON REDUCING BLOOD LOSS WITH REPEAT C-SECTIONS
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Keywords
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Abstract
INTRODUCTION
Anemia in women has been widely evaluated, studied and prevention with management measures have been implemented as a national programme. Blood loss from menstruation and delivery apart from nutritional cause have been attributed as major causes of acute and chronic anemia. Use of antifibrinolytic agent has been adopted in management of atonic post-partum hemorrhage and in gynec patients leading to abnormal uterine bleeding. In this Study, we interd to study the role of tranexemic acid administered along with induction of regional anesthesia in patients undergoing repeat C-sections. The study population was chosen as Repeat C-sections pose more threat to excessive blood loss due to previous uterine scar, tissueand bladder adhesions, impending rupture uterus and predisposition to atonic post-partum hemorrhage.
Aim
To evaluate the efficacy of tranexamic acid in reducing blood loss in repeat C-sections.
Objectives
To compare the drop in post-operative hemoglobin and intra Operative blood loss. To evaluate the effect of pre-operative hemoglobin and infant birth weight to suggest safe use of tranexemic acid in the perinatal period to prevent anticipated excessive blood loss. .
MATERIALS AND METHODS
Study Material
All antenatal patients presenting for repeat C-section delivery to the obstetrics OP with no systemic co-morbidities.
Study Period- September. 2024 TO December. 2024
Study- Prospective Observational Study
Study Sample- 48
Methods
All antenatal patients presenting to obstetrics OP under ASA I and II with history of previous C-section now admitted for repeat C-section were included in the study. Through antenatal workup, counselling and consent were obtained. The BMI, Pre-operative and post- operative hemoglobin, amount of blood loss in the form of number of soaked pads and gauzes apart from suction content, infant birth weight were noted and tabulated. All patients received 500mg Tranexemic acid in 100ml normal saline intravenous over a period of 7-10 minutes as soon as they were placed on the table and the monitors were connected.
RESULTS
No reactions or hemodynamic changes due to tranexemic acid were noted in ant of the patients. An average of 4 full soaked gauzes and 3-4 fully soaked moping pads (dry weight- 30gms) were noted in all patients. No extra dose of tranexemic acid was needed in patients with higher BMI. Infant birth weight was unaffected with blood loss or BMI or hemoglobin levels.
CONCLUSION
Tranexemic acid can be safely used during induction of anesthesia in repeat C-sections with minimal blood loss and nil side effects.
References
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Dr. Srinandhini
Assistant Professor, Department of Obstetrics and Gynaecology, Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, Perambalur, Tamil Nadu, India.
Dr. Geetha J
Associate Professor, Department of Anesthesialogy, Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, Perambalur, Tamil Nadu, India.
Dr. Nuzhat Zeba
Associate Professor, Department of Obstetrics and Gynaecology, Dhanalakshmi Srinivasan Medical College and Hospital, Siruvachur, Perambalur, Tamil Nadu, India.