MICRONEEDLE-MEDIATED DELIVERY OF LEVALBUTEROL FOR PEDIATRIC ASTHMA: FORMULATION DEVELOPMENT AND PHARMACOKINETIC EVALUATION
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Keywords
Pediatric, Asthma, Levalbuterol, Microneedle
Abstract
It is challenging to manage pediatric asthma due to the frequent administration of medications and the difficulty of using conventional inhalers by young children. Our study explores microneedle-mediated delivery as a novel method for administering levalbuterol, a β2-adrenergic agonist commonly used to treat pediatric asthma. There are many advantages to transdermal drug delivery, but there are also some drawbacks. Certain drugs cannot penetrate the skin barrier effectively, so transdermal delivery may not be feasible. A number of factors can also affect the permeability of the skin, such as thickness, hydration, hair follicles, and sweat glands. There are a number of medications that can be administered via transdermal delivery. Medication compliance is improved and convenience is provided. Asthma patients treated with microneedle-mediated levalbuterol demonstrated feasibility and effectiveness. The results of this study suggest that microneedle technology has the potential to be a safe, effective, and patient-friendly alternative to traditional inhalers for the delivery of asthma medication to pediatric patients.
References
2. Sonia Dhiman,Thakur Gujarath Singh, Ashik Kumar Rehni.Transdermal patches: A recent approach to new drug delivery system. Int J Pharm Pharm Sci. 2011; 3(5): 26- 34.
3. Tajashree Waghule, Gautam Singhvia, Sunil Kumar Dubeya, Murali Monohar Pandeya, Gaurav Guptab, Mahaveer Singh et al. Microneedle: A smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019; 109: 1249-158.
4. Pablo Serrano-Castaneda, José Juan Escobar-Chávez, Isabel Marlen Rodríguez- Cruz,Luz María Melgoza-Contreras1, Jessica Martínez-Hernández e. Microneedles as enhancer of drug absorption through the skin and applications in medicine and cosmetology. J Pharm Pharm Sci. 2018; 21: 73-93.
5. Valsa Remony Manoj, Hima Manoj. Review on transdermal microneedle based drug delivery. Asian J Pharm Clin Res. 2019; 12(1): 18-29.
6. Hiep X.Nguyen, Behnam Dasht Bozorga , Yujin Kima , Alena Wieberb, Gudrun Birkb, Dieter Lubdab,et al., Polyvinyl acohol microneedle: Fabrication, characterisation and application for transdermal drug delivery of doxorubicin. Eur J Pharm Biopharm. 2018; 129(88): 103-113.
7. Yanqi Ye, Jicheng Yu, Di Wen, Anna R. Kahkoska, Zhen Gu. Polymeric microneedle for protein delivery. Adv Drug Deliv Rev. 2018; 18: 300-323.
8. Maelisoa TC McCrudden, Ahlam Zaid Alkilani, Cian M McCrudden, Emma McAlister A, Helen O McCarthy A, A David Woolfson , Ryan F Donnelly. Design and physiochemical characterisation of novel dissolving polymeric microneedle arrays of transdermal delivery of high dose, low molecular weight drugs. J Control Release. 2014; 180: 71-80.
9. Min Wang, Lianzhe Hub and Chenjie Xu . Recent advance in the design of polymeric microneedles for transdermal drug delivery and biosensing. RSC.LIC/LOC. 2017;10:1039.
10. Lanke SSS, CS Kolli , JG Stroma, AK Banga. Enhanced transdermal delivery of low molecular weight heparin by barrier perturbation. Int J Pharm. 2019; 365: 26-33.
11. Leone M, J Monkare, JA Bouwstra1, G Kersten. Dissolving microneedle patches for dermal vaccination. Pharm Res. 2017; 34(11): 2223-2240.
12. Mary-Carmel Kearney, Ester Caffarel-Salvador, Steven J Fallows, Helen O McCarthy, Ryan F Donnelly. Microneedle mediated delivery of donezepil:potential for improve treatment option in Alzheimers disease. Eur J Pharm Biopharm. 2016; 103: 43-50.
13. Chi Lee, Jheng-Siou, Meng-Tsan Tsai, Kai-Che Lin. Fabrication of novel partial dissolving polymer microneedle patch for transdermal delivery. J Mater Chem. 2014; 12(48): 2-30.
14. Yukako Ito, Aiko Murakami, Tomohiro Maeda, Nobuyuki Sugioka, Kanji Takada. Evaluation of self dissolving needle containing low molecular weight heparin in rat. Int J Pharm. 2007; 349: 124-129.
15. Shubhmita Bhatnagar, Neha Gajanan Bankar, Mrunal Vijay Kulkarni, Venkata Vamsi Krishna Venuganti. Dissolvable microneedle patch containing doxorubicin and docetaxel is effective in 4T1 xenografted breast cancer mouse model. Int J Pharm. 2019; 10: 263-275.
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Venkatesh K, Komala M
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai - 600117, Tamilnadu, India.