Effect of CoQ10 Administration to Psoriatic Iraqi Patients on Biological Therapy Upon Severity Index (PASI) and Quality of Life Index (DLQI) Before and After Therapy.
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Keywords
PASI, DLQI, CoQ10, Psoriasis, Biological Therapy.
Abstract
Psoriasis is a medical condition in which the skin of the body is affected in a multisytemic level. Patients with moderate to severe psoriasis have a considerably reduced quality of life as a result of their disease. For morphological indicators, The Psoriasis Area Severity Index (PASI) test is one of the methods that have been tested for indicating the severity of the illness.An imbalance between pro-oxidants and antioxidants in our bodies causes oxidative stress to play a crucial role in the pathophysiology of chronic inflammatory diseases like psoriasis(1).It has been considered that antioxidant treatment can turn out to be an effective therapeutic option. The goal of this clinical investigation was to see if there was a link between the percentage change in quality of life and the clinical severity of psoriasis during a 12-week period among Iraqi psoriatic patients. Over the course of three months, 24 psoriatic patients (9 females and 15 males) ranging in age from 17 to 72 years old participated in a prospective double-blind clinical experiment. Two groups of participants were formed. A biological medicine (Adalimumab) and a placebo was given to group A (n=11), while group B (n=13) received 100 mg CoQ10 adjuvant therapy in addition to the biological medication already provided. The Psoriasis Area and Severity Index (PASI) and the Dermatology Life Quality Index (DLQI) were used to examine patients (DLQI). From treatment, with both biological and adjuvant CoQ10 therapy, showed a substantial association between the PASI and the DLQI (p value = 0.000132). After three months of therapy, the mean SD of PASI score for all patients was 20.88 7.15, with a 67.48 22.25032 percent improvement change. The mean SD of the DLQI score at baseline was 12.5 4.71, with a change of 56.13 20.15 percent following treatment. After therapy with a biological medication, there was a favorable association between the PASI and the DLQI (p>0.05). This indicates that therapy with a biological medication with daily administration of 100 mg CoQ10 supplements to psoriatic patients for 12 weeks improved the correlation between the PASI and DLQI.
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