ASSOCIATION OF Α-TNF AND IRON PARAMETERS IN ANEMIC AND NON-ANEMIC PTB
Main Article Content
Keywords
Anemia, Pulmonary tuberculosis, α-tumor necrosis factor, Iron, ferritin
Abstract
Background: Tuberculosis has been major killer globally since the centuries and has now become a tenth leading cause of death worldwide. It is an air-borne chaos that induces systemic inflammation and have commonly linked with different comorbid clinical condition such as anemia. In chronic diseases such as pulmonary tuberculosis (PTB), inflammation due to bacterial burden play a vital role in Patho-physiology of anaemia.
Methodology: A comparative type of case control study. The study included 40 newly diagnosed anemic PTB (cases) and 40 newly diagnosed non anemic PTB (controls) of either gender having age group of 20-70 years. The PTB was confirmed by microscopic examination of sputum specimen for the detection of Acid-Fast Bacilli (AFB). Serum iron was analyzed by ferrozine method and α-TNF were analyzed by ELISA method. SPSS 20 version were used for the statistical analysis.
Results: Significantly higher levels of α-TNF (225.77±77.49) were observed in anemic PTB cases than that of non-anemic PTB cases (p<0.001). Significantly inverse correlation was observed between α-TNF and iron(p<0.05) and positive association between α-TNF and Ferritin (p<0.05) in both the groups.
Conclusion: Increased α-TNF leads to higher bacterial burden and lower iron levels.
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Dr Priti Yadav
Associate Professor, Department of Biochemistry, MGM Medical College and Hospital, Nerul, Navi Mumbai
Dr Sadhna Ajay
Associate Professor, Department of Biochemistry, Autonomous Medical College, Jaunpur, UP.
Dr Farhat Fatima
Assistant Professor, Department of Biochemistry, Autonomous Medical College, Jaunpur, UP.
Dr. Ashish Agarwal
National Capital Region Institute of Medical Sciences, Meerut, UP