TO ASSESS THE IMPACT OF VITAMIN D SUPPLEMENTATION ON PROTEINURIA IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS, CONSIDERING THE AVERAGE ALTERATION IN THE URINARY ALBUMIN/CREATININE RATIO (UACR)
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Keywords
Vitamin D, Type 2 Diabetes Mellitus, proteinuria, urinary albumin-to-creatinine ratio, diabetic nephropathy, supplementation.
Abstract
Introduction: Vitamin D is normally low in T2DM patients and low levels make the damage of diabetic kidneys worse. Blood tests formerly known as UACR help to determine levels of proteins in urine to identify kidney damage at its early stages in patients with T2DM.
Objectives: The present study was designed to measure the efficacy of vitamin D supplementation in modifying proteinuria in T2DM patients through the evaluation of UACR after 6 months.
Materials and Methods: A group of investigators conducted a trial with 150 patients afflicted by both type-2 diabetes and high urinary albumin excretion by forming groups. The study divided the subjects into two equal groups and administered 1000 IU of vitamin D daily supplements to the first group while the second group was given a placebo for six months.
Results: The vitamin D intervention was also found to have achieved better outcome in the lowering of UACR than the placebo group and improved the serum levels of vitamin D.
Conclusion: Vitamin D helps reduce protein loss from the kidneys of type 2 diabetes patients to stop the progression of kidney damage.
References
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Kalsoom Ali Shah
Jinnah Medical College, KPK, Pakistan
Muhammad Junaid
Registrar, Department of Rheumatology, University Hospital Waterford, Ireland
Usman Saeed
Associate Professor, Department of Pharmacology, Fatima Memorial Hospital College of Medicine & Dentistry, Pakistan
Talal Safdar
Assistant Professor of Medicine, Fauji Foundation Hospital Rawalpindi, Pakistan
Bisma Fatima Aslam
Assistant Professor, Department of Pharmacology & Therapeutics Azra Naheed Medical College, Lahore, Pakistan
Sauda Usmani
Associate Professor, Department of Physiology, Pak Red Crescent Medical and Dental College Lahore, Pakistan