THYROID HORMONAL CHANGES IN CHRONIC KIDNEY DISEASE: A STUDY OF ENDOTHELIAL FUNCTION AND ALBUMINURIA
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Keywords
Thyroid Hormone, Chronic Kidney Disease, Endothelial Function, Albuminuria
Abstract
Introduction: Endothelial dysfunction is closely linked to both albuminuria and thyroid dysfunction. Albuminuria, the presence of albumin in the urine, is a well-established marker of kidney damage and is associated with an increased risk of cardiovascular disease in CKD patients. Albuminuria is one of the earliest signs of kidney injury and is a strong predictor of adverse outcomes in CKD patients. It is an independent risk factor for both the progression of kidney disease and the development of cardiovascular events.
Material & Methods: An observational, case control study was carried out for 2 years with a Sample Size of 180 with two groups1 (n=90): CKD subjects and group 2 (n=90): Non-CKD subjects. Estimation of Kidney functions, Estimation of Endothelial Function, Estimation of Albumin level was assessed by albumin-to- creatinine ratio (ACR) and Estimation of Thyroid function was done.
Results: The study revealed notable differences in serum creatinine, urea, TSH, and fT3 levels between the two groups, while serum fT4 levels remained unchanged. The biological parameters, including fT3, creatinine, urea, and fT4, exhibit distinct correlations with GFR in different stages of CKD, emphasizing the relationship between kidney function and thyroid hormone levels.
Conclusion: Alterations in thyroid function, particularly hypothyroidism, can exacerbate endothelial injury, contributing to vascular dysfunction and kidney damage. Endothelial dysfunction, in turn, plays a pivotal role in the development of albuminuria, a key marker of kidney injury.
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Shaivya Morwal
PhD Scholar, Department of Biochemistry, Index Medical College Hospital & Research Centre, Indore M.P.
Ashutosh Jain
Assistant Professor, Department of Physiology, Index Medical College Hospital & Research Centre, Indore M.P.
Jaya Jain
Associate Professor, Department of Biochemistry, Index Medical College Hospital & Research Centre, Indore M.P.