ANTIMICROBIAL RESISTANCE PATTERN OF KLEBSIELLA OXYTOCA AMONG CLINICAL SPECIMENS IN A TERTIARY CARE HOSPITAL
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Keywords
K. oxytoca, Gentamicin, Antibiotic resistance, Multi Drug resistant organisms (MDRO)
Abstract
Objective:The purpose of the study was to determine Klebsiella oxytoca's pattern of antibiotic resistance among clinical specimens.
Methods:A total of 1683 clinical samples were processed. A modified Kirby-Bauer disc diffusion method was used to test for antibiotic sensitivity patterns. The double disc synergy test was used to confirm ESBL production among Klebsiella spp.
Results:Of the 1683 clinical samples processed, 121 isolates were Klebsiella species. Thirty-two (32.2%) of these isolates were K. oxytoca which exhibited 100% resistance to Cefoxitin followed by Ceftazidime, Ciprofloxacin, Imipenem, Meropenem and Gentamicin by 86%, 67%, 59%, 56%, and 46% respectively which is comparable to K. pneumoniae whereChloramphenicol was determined to be the most promising medication, followed by Fosfomycin. 70% of the isolates of K. oxytoca had multidrug resistance.
Conclusion:Hospitals should maintain a strict antibiotic policy in order to track the effects of growing bacterial resistance and take preventative measures against K. oxytoca.
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Dr. Sandhya Rani.T
Department of Microbiology, Katuri medical college and hospital,Guntur
Dr.K. Saileela
Department of Microbiology, Kamineni institute of medical sciences, Narketpalle, Telangana
Dr.M. Shabnum
Department of Microbiology, Katuri medical college and hospital,Guntur