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Pletnev Vladimir Vladimirovich,


Alkaline eye burn, Medicine No. 1, Pletnev drops, Anti-inflammatory effect, Wound healing effect.


Studies have shown that the medicine No. 1 at a dose of 0.05 ml/kg in 1:15 dilution with a sterile saline solution, when instilled into both eyes of rabbits 2 times a day for 30 days after an alkaline burn has an anti-inflammatory, wound-healing and angioprotective effects. Under the influence of the medicine No. 1 in the test dose, there is a stimulation of reparative processes in the cornea, which is manifested by accelerating the recovery of defects in the anterior epithelium and stroma, reducing the frequency of formation of deep defects, reducing the severity of the inflammatory reaction and vascularization, inhibiting the formation of turbidity of its lower intensity and area. Under the action of drug No. 1, there was a tendency to restore stroma laminosity throughout the observation period, which contributed to a decrease in the degree of vascularization and prevented ulceration and perforation of the cornea. By the end of the experiment, there was a restoration of strong epithelial-stromal relationships in the experimental group compared with the control, due to the formation of normal architectonics of fibrous components of the intercellular substance. In the limbal zone of the cornea of the eye in rabbits of the experimental group, compared with the control, there was a more pronounced proliferative activity, with an increase in the layering of limbal epithelial cells.

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1. Asgarpanah, J. et al. Phytochemistry and pharmacological properties of Equisetum arvense L. Journal of Medicinal Plants Research, 2012. – Vol. 6(21). – P. 3689-3693. []
2. Boloor, K.K., Kamat, J.P., Devasagayam, T.P. Chlorophyllin as a protector of mitochondrial membranes against gamma-radiation and photosensitization. Toxicology, 2000. – Vol. 155(1-3). – P. 63-71. []
3. Burns. / Edited by Panamonov B.A., Porembsky Y.O., Yablonsky V.G. – Saint Petersburg: Publishing house “SpecLit”, 2000. – 486 p. []
4. Danilo Maciel Carneiro, Ramias Calixto Freire,Tereza Cristinade Deus Honório, Iury Zoghaib, Fabiana Fernandesde S. eSilva Cardoso, Leonice Manrique F. Tresvenzol, José Realinode Paula, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Luiz Carlosda Cunha1, Research Article Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum arvense (Field Horsetail) in Healthy Volunteers, Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume, 2014. – Article ID 760683. – P. 8. []
5. Do Monte et al. Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of stems from Equisetum arvense L. in mice. Pharmacological research, 2004. – Vol. 49. – P. 239-243. []
6. Eye burns: a handbook for doctors. / Edited by Neroev V.V. – Мoscow: Publishing house “GEOTAR-Media”, 2013. – 224 p. []
7. Eye burns. / Edited by Puchkovkaya N.А., Yakimenko S.A., Nepomnyaschaya B.M. – Мoscow: Publishing house “Medicine”, 2001. – 268 p. []
8. Eye burns. The condition of the problem and new approaches. / Edited by Chernish V.F., Boyko E.V. – Мoscow: Publishing house “GEOTAR-Media”, 2017. – 184 p. []
9. Кisileva, T.L., Smirnova, Yu.A. Medicinal plants in the world medical practice. – Мoscow: Publishing house “Professional Association of Natural Therapists”, 2009. – 295 p. []
10. Mekhfi, H., Haouari, M.E., Legssyer, A., Bnouham, M., Aziz, M., Atmani, F., Remmal, A., Ziyyat, A. Platelet anti-aggregant property of some Moroccan medicinal plants, J. Ethnopharmacol., 2004. – Vol. 94 (2-3). – P. 317-322. []
11. Milovanovic, V., Radulovic, N., Todorovic, Z., Stankovic, M., Stojanovic, G. Antioxidant, antimicrobial and genotoxicity screening of hydro-alcoholic extracts of five serbian Equisetum species, Plant Foods Hum. Nutr., 2007. – Vol. 62 (3). – P. 113-119. []
12. Mimica-Dukic, N., Simin, N., Cvejic, J., Jovin, E., Orcic, D., Bozin, B. Phenolic compounds in field horsetail (Equisetum arvense L.) as natural antioxidants, Molecules, 2008. – Vol. 13(7). – P. 1455-1464. []
13. Miwa, Y., et al. Asafety toxicology study of Equisetum arvense L. Pharmacometrics, 2009. – Vol. 76. – P. 61-69. [ study_of_equisetum_arvense_L]
14. Nagai, T., Myoda, T., Nagashima, T. Antioxidative activities of water extract and ethanol extract from field horsetail (tsukushi) Equisetum arvense L., Food Chem., 2005. – Vol. 91(3). – P. 389-394. [ water_and_ethanol_extract_from_field_horsetail_tsukushi_Equisetum_arvense_L]
15. Pletnev, V. Study of the therapeutic effect of Pletnev drops No. 1 (drug No. 1) on a model of alkaline corneal burn in rabbits. / The scientific heritage, Budapest, Hungary, 2020. – Vol. 3 (46). – Р. 58-61. []
16. Radulovic, N., Stojanovic, G., Palic, R. Composition and antimicrobial activity of Equisetum arvense L. essential oil, Phytother Res., 2006. – Vol. 20(1). – P. 85-88. []
17. Santos, J.G.D. Jr., Blanco, M.M., Monte, F.H.D., Russi, M., Lanziotti, V.M., Leal. L.K., Cunha, G.M. Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense, Fitoterapia, 2005. – Vol. 76(6). – P. 508-513. []
18. Stajner, D., Popovic, B.M., Canadanovic-Brunet, J., Boza, P. Free radical scavenging activity of three Equisetum species from Fruska gora mountain Fitoterapia, 2006. – Vol. 77(7-8). – P. 601-604. []
19. Stajner, D., Popovic, B.M., Canadanovic-Brunet, J., Anackov, G. Exploring Equisetum arvense L., Equisetum ramosissimum L. and Equisetum telmateia L. as sources of natural antioxidants, Phytother. Res., 2009. – Vol. 23 (4). – P. 546-550. [pubmed.ncbi.nlm.nih. gov/19067388/]
20. Tago, Y., Wei, M., Ishii, N., Kakehashi, A., Wanibuchi, H., Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats, J. Toxicol. Pathol., 2010. – Vol. 23 (4). – P. 245-251. []
21. Wagoner, M.D. Chemical injuries of the eye: Current concepts in pathophysiology and therapy / Survey of Ophthalmology, – 1997. – Vol. 41. – P. 275-31. [pubmed.ncbi.nlm.nih. gov/9104767/]
22. WHO. Monographs on medicinal plants commonly used in the newly independent states. – 2010. – 450 p. [ 2010.pdf]