AGE-RELATED VARIATIONS IN CLINICOPATHOLOGICAL FEATURES OF GASTRIC CANCER: A RETROSPECTIVE ANALYSIS FROM A TERTIARY CARE HOSPITAL
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Keywords
Gastric Cancer, Clinicopathological Features, Retrospective Analysis, Age, Tumor Characteristics
Abstract
Background: Globally, gastric cancer is the third leading cause of cancer-related deaths, with late-stage diagnosis and minimal screening making it challenging to manage in Pakistan.
Objective: The aim of this study is to investigate the association between age and clinicopathological features of Gastric cancer patients in a tertiary care hospital so as to serve as a guide towards early diagnosis
Methodology: A retrospective analysis of 123 gastric cancer patients treated at Khairpur Medical college teaching Hospital, Khairpur Mir’s,from April 2021 to April 2024 was conducted. The study included age, gender, symptoms, tumor characteristics, and histological findings. Variables were evaluated using SPSS version 22, and the chi square test was used to assess the relationship between age groups and categorical factors such as tumor size, tumor site, grade, T stage, N stage, and M stage.
Results: The majority of patients were aged 40-60 years (47.15%), with a male predominance (65.04%). Common symptoms included abdominal discomfort (70%) and weight loss (58%). Tumors were predominantly located in the antrum (35.77%), with 74.80% smaller than 5 cm. poorly differentiated tumors were observed in 43.09% of cases. Tumor size and grade varied significantly with age; smaller tumors (<5 cm) were more common in the 40-60 age group (p = 0.032), while older patients (>60 years) often had well-differentiated tumors (p = 0.010). Advanced stages (T3, N2, and M1) were more prevalent in older individuals (p < 0.05).
Conclusion: Age significantly affects gastric cancer clinicopathological features, with older patients showing advanced stages and well-differentiated tumors, highlighting the need for early detection
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Dr. Syed Sohail Abbas Naqvi
MBBS, RMP, MPhil, Associate Professor Pathology, Khairpur Medical College Khairpur Mir's
Dr. Nisar Ahmed
MBBS, M. Phil (Anatomy), Senior Demonstrator, Suleman Roshan Medical College, Tandoadam, Pakistan
Dr. Zulfiqar Ali Shar
MBBS, FCPS, Professor Department of General Surgery, Khairpur Medical College, Khairpur Mir’s, Pakistan
Dr. Maryam Waqar Panhwar
MBBS, M.Phil. Scholar Anatomy, MCPS (Obstetrics and Gynaecology), Diploma (Facial Aesthetics), Diploma (Aesthetic Gynaecology), Demonstrator, Department of Anatomy, Khairpur Medical College, Khairpur Mir’s, Pakistan
Dr. Asad Ali Zardari
MBBS M.Phil. (Anatomy), Assistant Professor, Department of Anatomy, Peoples University of Medical and Health Sciences for Women, Nawabshah SBA, Pakistan
Dr. Bhawani Shanker
MBBS, MPhil, Associate Professor of Pathology, Muhammad Medical College, Mirpur Khas, Pakistan