COMPARISON OF PREOPERATIVE NEBULIZATION WITH MAGNESIUM SULPHATE AND KETAMINE IN REDUCTION OF INCIDENCE OF POSTOPERATIVE SORE THROAT - AN OBSERVATIONAL COMPARATIVE STUDY
Main Article Content
Keywords
Postoperative sore throat, Nebulization, Magnesium sulfate, Ketamine, Intraoperative complications, Anesthesia
Abstract
Postoperative sore throat (POST) is one of the complications, which manifests itself as some amount of discomfort in patients who have undergone an operation. This review aimed to evaluate the role of preoperative nebulization with either MgSO4 or ketamine or the prevention of new POST formation. MgSO4 and ketamine may lower pain and inflammation caused by the tube inserted into the throat. We discuss the action, efficacy, and safety of both MgSO4 and ketamine nebulization intentionally. Remarkably, ±MgSO4 and ketamine have been shown to decrease the incidence and severity of POST in comparison to the control groups combined with a low risk of side effects. Ketamine had a better pain relief measurement at virtually all the postoperative time points. The interaction between MgSO4 and ketamine shows that there is likely synergism: further study is nevertheless sparse. Some of them are Sterile compounding of solutions for nebulization before anesthetic induction. Subsequent, prospective double-blinded randomized controlled trials, enumerating doses of combined therapy, and probable modes of administration should be performed. In totality, preoperative nebulization with MgSO4 and/or ketamine reduces POST through anti-inflammatory and antinociceptive pathways, and there is a slightly higher therapeutic gain with ketamine.
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Oct 29, 2024
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Dr.K. Brinda, Dr. Shiny Priya Darshini aarumulla, Dr.Vijetha Devaram, Dr. Yannabattini Sangeeth Vihari, Dr. Valluri Anil Kumar, & Dr.Haritha Damarla. (2024). COMPARISON OF PREOPERATIVE NEBULIZATION WITH MAGNESIUM SULPHATE AND KETAMINE IN REDUCTION OF INCIDENCE OF POSTOPERATIVE SORE THROAT - AN OBSERVATIONAL COMPARATIVE STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 31(10), 566-583. https://doi.org/10.53555/s9pm0k14
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Author Biographies
Dr.K. Brinda
Associate Professor, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh, INDIA
Dr. Shiny Priya Darshini aarumulla
Associate Professor, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh , INDIA
Dr.Vijetha Devaram
Associate Professor, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh , INDIA
Dr. Yannabattini Sangeeth Vihari
Post graduate, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh, INDIA
Dr. Valluri Anil Kumar
Professor, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh, INDIA
Dr.Haritha Damarla
Assistant Professor, Department of anaesthesiology, Narayana medical college, Nellore, Andra pradesh, INDIA
How to Cite
Dr.K. Brinda, Dr. Shiny Priya Darshini aarumulla, Dr.Vijetha Devaram, Dr. Yannabattini Sangeeth Vihari, Dr. Valluri Anil Kumar, & Dr.Haritha Damarla. (2024). COMPARISON OF PREOPERATIVE NEBULIZATION WITH MAGNESIUM SULPHATE AND KETAMINE IN REDUCTION OF INCIDENCE OF POSTOPERATIVE SORE THROAT - AN OBSERVATIONAL COMPARATIVE STUDY. Journal of Population Therapeutics and Clinical Pharmacology, 31(10), 566-583. https://doi.org/10.53555/s9pm0k14