Comparison Of The Effects Of Ivermectin, Permethrin & Gamma Benzene Hexachloride Alone And With That Of Combination Therapy For The Management Of Scabies. Effect and Safety of Scabicidal drugs

Main Article Content

Saborni Dey
Sachin Agarwal
Sagar

Keywords

Permethrin & Ivermectin efficacy

Abstract

ABSTRACT :


The present study compared three scabicidal agents alone or with combination - the currently considered medicine of choice permethrin, oral ivermectin and gamma benzene hexachloride in the local population of India.


A total of 120 patients were enrolled and randomly divided into 4 groups. Group A received topical 5% permethrin & oral placebo, Group B was given topical placebo cream & oral ivermectin in two dose regimen. Group C received topical 1% gamma benzene hexachloride with oral placebo & Group D was given topical 5% permethrin & oral ivermectin. The improvement of lesions & pruritus were assessed in the next 3 follow ups i.e. at the 7th day, 14th day, & 28th day along with any adverse drug reactions (ADRs).


Group A had 83%, 90%, 97% while Group B had 70%, 81% & 91% improvement of lesions in 3 follow ups. Group C showed 57%, 70%, 86% and Group D had 82%, 90%, 97% efficiency to decrease lesion count.(p>0.05) Again Group A observed 77%, 88%, 94% improvement in pruritus in subsequent follow ups, while for Group B it was 63%, 76% & 86%. Group C had 55%, 71%, 85% efficiency and Group D had recorded 77%, 88% & 94% improvement to decrease pruritus.(p>0.05) The incidence of adverse effects was found to be less in Group B, Group C & Group D when compared to Group A. 


Conclusion : Group D or combination therapy was a better choice for scabies in comparison to other monotherapy due to its better efficacy and safety profile.


 Keywords : Scabies, permethrin, ivermectin, gamma benzene hexachloride.

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