SAFETY AND EFFICACY OF LONG PULSED 1064NM ND:YAG LASER VERSUS LIQUID NITROGEN CRYOTHERAPY FOR THE TREATMENT OF WARTS – A COMPARATIVE STUDY.
Main Article Content
Keywords
Warts, long-pulsed 1064 nm Nd, YAG laser, liquid nitrogen cryotherapy
Abstract
Background
Warts are benign epidermal growths on the skin and mucous membrane caused by infection with human papillomavirus. Complete clearance is not always achieved with the conventional therapies. Previous studies have shown the effectiveness of long pulsed 1064 nm Nd: YAG laser in the treatment of warts.
Objective
To compare the safety and efficacy of LP 1064 nm Nd: YAG laser with liquid nitrogen cryotherapy for the treatment of warts.
Methods
A total of sixty patients with warts were equally divided into two groups. First group received LP Nd: YAG laser treatment once in every four weeks for 16 weeks. Second group received liquid nitrogen cryotherapy once weekly for 4 weeks or until clearance of warts, whichever was earlier. Follow up was done at 4 and 8 weeks in laser group and at 2 and 4 weeks in cryotherapy group.
Results
The laser group demonstrated a significantly higher clearance rate (90.0% vs. 56.6%, p<0.01), requiring fewer treatment sessions (1.3 ± 0.5 vs. 2.8 ± 1.1, p < 0.01) compared to cryotherapy group. Laser group also had lesser complications and a lower relapse rate (0.0% vs. 13.3%, p=0.05) compared to cryotherapy group.
Conclusion
LP 1064nm Nd: YAG laser is a safer and therapeutically more effective treatment modality requiring lesser number of treatment sessions, lesser complications and lower relapse rates compared to liquid nitrogen cryotherapy.
References
2. Ghadgepatil SS, Gupta S, Sharma YK. Clinicoepidemiological study of different types of warts. Dermatol Res Pract. 2016;7989817: 1-4
3. Goldberg DJ, Beckford AN, Mourin A. Verruca vulgaris: Novel treatment with a 1064 nm Nd: YAG laser. J Cosmet Laser Ther. 2015 4;17(2):116-9.
4. Belman M, Shenoy MM, Vishal B, Pinto M, Hegde SP, Asfiya A. A retrospective analysis of the therapeutic effectiveness of 1064nm long pulsed neodymium: yttrium aluminum garnet laser in common warts: An Indian study. Indian J Dermatol Venereol Leprol. 2020;86(6):730-7332.
5. Bourke JF, Berth-Jones J, Hutchinson PE. Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. Br J Dermatol. 1995;132(3):433-436.
6. Albalat W, Attwa E, Ebrahim HM. Intralesional cryotherapy versus cryotherapy spray for the treatment of recalcitrant plantar warts: a prospective, randomized study. J Dermatolog Treat. 2022 Mar;33(2):857-863.
7. Nguyen J, Korta DZ, Chapman LW, Kelly KM. Laser Treatment of Nongenital Verrucae: A Systematic Review. JAMA Dermatol. 2016;152(9):1025-1033.
8. Khattab FM, Khashaba SA. Evaluation of combined treatment with long-pulsed neodymium- doped yttrium aluminum garnet laser and potassium hydroxide for the treatment of recalcitrant wart: a prospective comparative study. J Dermatolog Treat. 2020 Feb;31(1):56-60.
9. Liu JJ, Li HT, Ren YY, Yang F, Cheng ZH, Xia TB, Liu JL, Cao XJ, Lu SC. Long-pulsed neodymium-doped yttrium-aluminum-garnet laser versus cryotherapy for the treatment of cutaneous warts: A randomized controlled trial. J Am Acad Dermatol. 2022 Dec;87(6):1328- 1335.
10. Gheisari M, Iranmanesh B, Nobari NN, Amani M. Comparison of long-pulsed Nd: YAG laser with cryotherapy in treatment of acral warts. Lasers Med Sci. 2019 Mar;34(2):397-403.
11. Iranmanesh B, Khalili M, Zartab H, Amiri R, Aflatoonian M. Laser therapy in cutaneous and genital warts: A review article. Dermatologic Therapy. 2021 Jan;34(1):e14671.