NOOTROPIC EFFECT OF POLYHERBAL FORMULATION ON SCOPOLAMINE INDUCED MEMORY IMPAIRMENT IN EXPERIMENTAL ANIMALS
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Keywords
Adoxa moschatellina, Alpinia galanga, Laurus nobilis, Pole climbing test, Social recognition test, Latency time
Abstract
The goal of the current investigation was to ascertain if an ayurvedic polyherbal formulation (PHF) might improve animal models' capacity for learning and memory. Three plant extracts—Adoxa moschatellina (AM), Alpinia galanga (AG), and Laurus nobilis (LN)—were suspended to create the produced PHF with additional excipients. Several behavioral paradigms were used to examine PHF's learning and memory in rats with scopolamine-induced memory impairment. The enzymatic levels of MDA (Malondialdehyde), GSH (Glutathione) and AChE (Acetylcholinesterase) in rats were measured by biochemical estimate. The treatment of PHF, according to the results, caused the duration of social investigation trial 2 (SIT2) to be much shorter than SIT1.Plant extracts dramatically reduced the latency time in the fourth and fifth sessions of the water maze test as compared to the first session. The MWM (Morris Water Maze) test showed a reduction in scopolamine-induced memory impairment after the administration of AM, AG, LN, and PHF. In the pole climbing test, the extracts and PHF were similarly successful in cutting down on latency time. Following treatment with extracts and PHF, biochemical measures showed an increase in GSH levels and a decrease in MDA and AChE levels. study's findings support the notion that PHF is a useful formulation for memory and learning processes that protects against scopolamine-induced memory impairment. Furthermore, it is desirable to separate the active ingredients from various plant extracts.
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Adiba Afreen
Research Scholar, Department of Pharmacy, Sunrise University, Alwar, Rajasthan.
Dr. Anil Kumar Middha
Professor, Department of Pharmacy, Sunrise University, Alwar, Rajasthan
Dr. Shaik Mohd Khasim
Professor, Department of Pharmacy, Shadan College of Pharmacy, Hyderabad, Telangana.
Dr. D.V. Kishore
Professor, Department of Pharmacy, Shadan College of Pharmacy, Hyderabad, Telangana