FORMULATIONS AND EVALUATION OF METOPROLOL TARTRATE ORODISPERSIBLE TABLET BY DIRECT COMPRESSION CO-PROCESSED BY USING EXCIPIENT ISABGOL
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Keywords
Metoprolol tartrate, orodispersible tablets,, Isabgol, formulation development, patient compliance, superdisintegrants, drug release, stability studies
Abstract
This study investigates the formulation and evaluation of orodispersible tablets (ODTs) of Metoprolol tartrate using Isabgol as a co-processed excipient. The primary goal was to enhance patient compliance, particularly for individuals with swallowing difficulties. A series of formulations were developed, incorporating various superdisintegrants, and subjected to thorough characterization. Evaluation of the powder blends demonstrated good flow properties, compressibility, and uniformity. Post-compression studies indicated satisfactory hardness, low friability, and acceptable disintegration times, with the optimized formulation exhibiting a disintegration time of 32 seconds. In vitro drug release studies showed that the optimized formulation released 99.02% of Metoprolol tartrate within 300 seconds. Stability studies confirmed the robustness of the formulation, maintaining its performance under different temperature conditions over four weeks. Overall, the results suggest that the developed ODTs can provide an effective and patient-friendly alternative to conventional tablet formulations.
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Laksha Kochar
Mahakal Institute of Pharmaceutical Studies (MIPS), Ujjain
Garvita Joshi
Mahakal Institute of Pharmaceutical Studies (MIPS), Ujjain
Safiya Bee
Mahakal Institute of Pharmaceutical Studies (MIPS), Ujjain
Narendra Gehalot
Mahakal Institute of Pharmaceutical Studies (MIPS), Ujjain
Vikas Jain
Mahakal Institute of Pharmaceutical Studies (MIPS), Ujjain