POSTMENOPAUSAL OVARIAN GRANULOSA CELL TUMOR: CASE REPORT
Main Article Content
Keywords
Gynecology, Granulosa Cell Tumor, Oncology, Ovarian granulosa cell tumour GCT, Low-grade cancer, Postmenopausal women, Vaginal bleeding, Early puberty, Total abdominal hysterectomy, Estrogen secretion, Surveillance, Tumor management
Abstract
Background: Ovarian granulosa cell tumours (GCTs) are typically low-grade cancers originating from the specific stroma of the ovary. They occur across all age groups but predominantly manifest in postmenopausal women.
Objective: This article aims to describe a case of GCT and discuss the recommended management strategies for this condition.
Methods: A detailed case study of a postmenopausal woman with a granulosa cell tumour (GCT) is presented. The treatment approach, including bilateral salpingo-oophorectomy and total abdominal hysterectomy, is discussed. The importance of disease staging and ongoing surveillance is emphasized. This study was conducted at Hayatabad Medical Complex, Peshawar, KPK Pakistan.
Results: In this case, the patient exhibited symptoms such as vaginal bleeding due to estrogen secretion and tumour growth into the abdominal cavity. Post-surgical management included regular clinical assessments and marker testing to monitor for recurrence.
Conclusion: The stage of the disease is the most significant prognostic factor for recurrence in GCT patients. Due to the high likelihood of recurrence, ongoing surveillance through clinical assessment and marker testing is recommended. This case highlights the importance of comprehensive management and follow-up in patients with ovarian GCT.
References
2. Akbarova, M., & Azimova, G. (2024). THE SIGNIFICANCE OF DETERMINING HORMONES AND TUMOR MARKERS IN BLOOD SERUM IN GRANULOSA CELL TUMOR, ITS RECURRENCES AND METASTASES. Экономика и социум(3-2 (118)), 27-30.
3. Amirkashani, D., Nasiri, S. J., Dadakhani, S., Mortazavi, N., & Khoshkbarforoushan, M. (2024). Vaginal bleeding imitated rape in a 6-year old girl, a case report about granulosa cell tumor as a reason of peripheral precocious puberty. International journal of surgery case reports, 117, 109546.
4. Busquets, M., Gonzalez-Bosquet, E., Muchart, J., Rovira, C., & Lailla, J. (2010). Granulosa cell tumor and endometrial cancer: a case report and review of the literature. European journal of gynaecological oncology, 31(5), 575.
5. da Costa, R. E. A. R., Silva, M. C. A., Cavalcante, E. C. X., Branco, R. d. O. C., Dos Reis, C. A., & Vieira, S. C. (2024). Granulosa cell tumor of the ovary: a series of 6 cases. The Pan African Medical Journal, 47.
6. Dogan, I., Aydin, E., Topuz, S., Saip, P., Salihoglu, M. Y., & Aydiner, A. (2024). Hormonal Therapy in Pretreated Patients With Recurrent Ovary Granulosa Cell Tumor. Journal of Pharmacy Practice, 37(1), 146-150.
7. Dolkar, T., Rayapureddy, A. K., Kadakia, N., Bellamkonda, A., & Kalavar, M. (2023). Recurrent Granulosa Cell Tumor in a Postmenopausal Woman: A Case Report and Literature Review. Cureus, 15(8).
8. Dwajani, S., Rajeev, N., Shreya, M., & Madhu, Y. (2024). Extra Ovarian Adult Granulosa Cell Tumor: A Rare Clinical Case Report. Indian Journal of Gynecologic Oncology, 22(1), 22.
9. Erdogan, O., Kilic, C., Cakir, C., Kilic, F., Oktar, O., Ersak, B., . . . Ozturk, C. (2024). Is adjuvant chemotherapy necessary for 2014 FIGO stage IC adult granulosa cell tumor?: Multicentric Turkish study. Asia‐Pacific Journal of Clinical Oncology, 20(1), 46-54.
10. Hassan, O. (2024). Germ Cell Tumors, Pathology of the Ovary. In Gynecologic Pathology (pp. 114-127): Springer.
11. Jang, N. R., Lee, D. H., Jang, E. J., Bae, Y. K., Baek, J., & Jang, M. H. (2018). Ovarian gynandroblastoma with a juvenile granulosa cell tumor component in a postmenopausal woman: A case report and literature review. Journal of Pathology and Translational Medicine, 52(5), 344-348.
12. Kolli, S. N., Agrawal, M., Khithani, Y., & Kotdawala, K. (2020). A rare case of adult granulosa cell tumor of ovary as a cause of huge abdominal mass and postmenopausal bleeding. Journal of Datta Meghe Institute of Medical Sciences University, 15(4), 675-678.
13. Mazouzi, C., Moussaoui, T., Benyahia, R., Bellouse, B., Bencharif, C., & Kerboua, E. (2024). Juvenile Granulosa Tumor of the Ovary: Case Report. SAR J Med Case Rep, 5(2), 23-26.
14. Naeem, S. B., Imran, M., Abbas, M., Majeed, M. A., Jamil, M. A., Samreen, M., & Siddiqui, N. (2024). Story of 20 Years of Triumph: A Case Report of Two Patients With Stage IV Granulosa Cell Tumor of the Ovary. Cureus, 16(4).
15. Nagy, A., Niu, N., Ratner, E., Hui, P., & Buza, N. (2024). Novel FOXL2 Mutation in an Ovarian Adult Granulosa Cell Tumor: Report of a Case With Diagnostic and Clinicopathologic Implications. International Journal of Gynecological Pathology, 10.1097.
16. Oktar, O., Korkmaz, V., Tokalıoğlu, A., Öztürk, Ç., Erdoğan, Ö., Uçar, Y., . . . Ersak, B. (2024). Prognostic factors of adult granulosa cell tumors of the ovary: a Turkish retrospective multicenter study. Journal of Gynecologic Oncology, 35(3).
17. Rustamadji, P., Wiyarta, E., Anggraeni, T. D., & Siregar, T. P. (2021). Adult granulosa cell tumor with minor foci of juvenile granulosa cell tumor in postmenopausal woman: A rare case report. International Journal of Surgery Case Reports, 88, 106531.
18. Schonäuer, L. M., Cerbone, M., Picardi, N., Cara, I., Damiani, G. R., Cicinelli, E., . . . Di Naro, E. The multidisciplinary challenge of giant ovarian tumours in postmenopausal morbidly obese women: a case report, review of the literature and meta-analysis.
19. Tjokroprawiro, B. A., Novitasari, K., Ulhaq, R. A., & Sulistya, H. A. (2024). Clinicopathological Analysis of Giant Ovarian Tumors. European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 100318.
20. Tokalioglu, A. A., Oktar, O., Sahin, M., Ozturk, C., Erdogan, O., Yildirim, H. E. K., . . . Yalcin, N. De ning the Relationship Between Ovarian Adult Granulosa Cell Tumors and Synchronous Endometrial Pathology: Does Ovarian Tumour Size Correlate With Endometrial Cancer?
21. Tokalioglu, A. A., Oktar, O., Sahin, M., Ozturk, C., Erdogan, O., Yildirim, H. E. K., . . . Yalcin, N. (2024). Defining the relationship between ovarian adult granulosa cell tumors and synchronous endometrial pathology: Does ovarian tumor size correlate with endometrial cancer? Journal of Obstetrics and Gynaecology Research.
22. Wang, Y., Wang, N., Zhang, X., Fu, Z., Pang, C., Zhang, Y., & Li, X. (2024). Adult-type granulosa cell tumor associated with elevated luteinizing hormone: Two rare case reports. Medicine, 103(7), e37069.
23. Watkins, J. C., & Young, R. H. (2024). Nonneoplastic Disorders of the Ovary. In Pathology of the Ovary, Fallopian Tube and Peritoneum (pp. 35-58): Springer.
24. Xiao, S., Du, J., Yuan, G., Luo, X., & Song, L. (2024). Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives. Reproductive Sciences, 1-16.
25. Yaacoub, S., Hajj, L., & Khairallah, A. (2024). A clinicopathological study about the epidemiology of granulosa cell tumors in Lebanon. BMC cancer, 24(1), 309.
26. Young, R. H. (2024). An Approach to Ovarian Tumor Diagnosis. In Pathology of the Ovary, Fallopian Tube and Peritoneum (pp. 145-178): Springer.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Yasmeen
Women Medical Officer, Women and Children Hospital Rajjar, Charsadda, KPK, Pakistan (b) Gynecology Department, Hayatabad Medical Complex, Peshawar, KPK, Pakistan
Dr. Zonara Qamar
Consultant Obstetrician & Gynaecologist, Medcity International Hospital & Plastic Surgery Islamabad, Pakistan
Sarah A Awad
MD, Faculty of Medicine, Misr University for Science and Technology, Egypt
Bakhtawar Abdul Jalil
Department of Clinical Imaging, Women Wellness and Research Center, Hamad Medical Corporation, Doha, Qatar