THE EVALUATION OF THE PATHOGENIC THRESHOLD IN REGIONS WITH HIGH PERMANENT TRANSMISSION OF MALARIA, AS WELL AS THE MEASUREMENT OF MALARIA-RELATED PNEUMONIA
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Keywords
Epidemiological surveys, Malaria endemic regions, Parasitemia evaluation, Micro-hematocrit smears, Parasite density measurement, Microscopy, Statistical analysis, Malaria diagnosis, Morbidity prevention
Abstract
Background: Epidemiological surveys in malaria-endemic regions with permanent transmission require a simple, rapid, and cost-effective method to evaluate parasitemia.
Objective: To develop and validate a method for measuring parasite density using micro-hematocrit red blood cell counts on smears.
Methods: Procedure: The parasite density was measured by counting the number of red blood cells in micro-hematocrit smears.
Microscopy: Parasitemia was assessed by reading 75 to 100 microscopic fields at 100x magnification.
Statistical Analysis: The formula for determining parasitemia was statistically justified and explained.
Results: Participants: 1,163 healthy individuals and 534 consultants were included.
Age Groups: Analysis was conducted across different age groups.
Thresholds for Harmful Parasitemia:
Children: Harmful parasitemia threshold ranged between 3,000 and 6,000 trophozoites per milliliter of blood.
Adults: Threshold was lower than 1,000 trophozoites per milliliter of blood.
Conclusion: The method developed for evaluating parasitemia is effective for epidemiological surveys in malaria-endemic regions. Maintaining the diagnosis of malaria at the established parasitemia thresholds is crucial to prevent morbidity.
References
2. Adediran, I. A. (2022). Societal And Public Health Measures Against The Effects Of Sars-Cov-2 On The Transmission Dynamics Of Malaria: A Mathematical Modelling Approach Mountain Top University].
3. Amimo, F. (2024). Malaria vaccination: hurdles to reach high-risk children. BMC medicine, 22(1), 111.
4. Brito, M., & Tchonhi, C. (2019). Protection against malaria in heterozygous girls for G6PD deficiency in Angola. American Journal of Tropical Medicine and Hygiene, 101(Suppl. 5), 299-299.
5. Cirera, L., Sacoor, C., Meremikwu, M., Ranaivo, L., Manun’Ebo, M. F., Pons-Duran, C., Arikpo, D., Ramirez, M., Ramponi, F., & Figueroa-Romero, A. (2023). Cost-effectiveness of community-based distribution of intermittent preventive treatment of malaria in pregnancy in Madagascar, Mozambique, Nigeria, and the Democratic Republic of Congo. BMJ Global Health, 8(7), e010238.
6. Durán, J. A., Tapia-Barredo, L., & Paulino-Ramírez, R. (2019). Descriptive analysis of vaccine-preventable diseases in the Dominican Republic: is public media counteracting the public health efforts? The American Journal of Tropical Medicine and Hygiene.
7. Fançony, C., Soares, A., & Brito, M. (2019). Effectivity of wash/malaria educational community-based intervention in reducing anemia among preschool children from Bengo, Angola. American Journal of Tropical Medicine and Hygiene, 101(Suppl. 5), 578-578.
8. Fink, G., Venkataramani, A. S., & Zanolini, A. (2021). Early life adversity, biological adaptation, and human capital: evidence from an interrupted malaria control program in Zambia. Journal of Health Economics, 80, 102532.
9. Galactionova, E. (2019). Economic and impact modeling to guide the introduction of new tools against malaria University_of_Basel].
10. Gwarinda, H. B. (2021). Genetic diversity of human malaria parasites associated with continued malaria transmission in pre-elimination settings in South Africa UNIVERSITY OF PRETORIA Pretoria, South Africa].
11. Kho, S., Qotrunnada, L., Leonardo, L., Andries, B., Wardani, P. A., Fricot, A., Henry, B., Hardy, D., Margyaningsih, N. I., & Apriyanti, D. (2021). Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study. PLoS medicine, 18(5), e1003632.
12. Kullaya, S. M. (2019). Evaluation of malaria morbidity trends in the complex humanitarian settings in northwestern Tanzania The Open University of Tanzania].
13. Morais, I., Rodrigues, S., Mas, A., Escalon, S., Borrego, A., Nogueira, F., & Antunes, M. L. (2024). Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area.
14. Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner Jr, D. A., & Marti, M. (2020). New insights into malaria pathogenesis. Annual Review of Pathology: Mechanisms of Disease, 15, 315-343.
15. Nyiro, J. U., Bukusi, E., Mwaengo, D., Nyaguara, A., Nyawanda, B., Otieno, N., Bigogo, G., Murunga, N., Widdowson, M.-A., & Verani, J. R. (2022). The efficiency of transplacental transfer of respiratory syncytial virus (RSV) specific antibodies among pregnant women in Kenya. Wellcome Open Research, 7.
16. Organization, W. H. (2019). Safer water, better health.
17. Organization, W. H. (2022). Global framework for the response to malaria in urban areas. World Health Organization.
18. Ssewanyana, I. (2021). P. falciparum Transmission Intensity and the Quality of Antimalarial Antibodies London School of Hygiene & Tropical Medicine].
19. Trasia, R. F. (2023). Parasitic Disease and COVID-19 Syndemics in Indonesia: Biomedical Aspects. International Islamic Medical Journal, 5(1), 58-77.
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Praveenkumar Periyasamy
Lecturer, Department Anatomy, Levy Mwanawasa Medical University, Lusaka, Zambia
Pragathi Munnangi
Graduate, Department of Internal Medicine, N.R.I Medical College, Guntur, India
Aliu Olalekan Olatunji
Doctor, Department of Medical Microbiology and Immunology, University of Toledo Ohio State, USA,
Bilal Fattani
House Officer, Department of Surgery, Jinnah Medical College Hospital, Pakistan
Mohit Lakkimsetti
MBBS, Mamata Medical College, Khammam, India
Abubakar Ali
University Institute of Medical Lab Technology, Faculty of Allied Health Sciences, The University of Lahore