IMPACT OF DELAYED ANTIBIOTIC ADMINISTRATION ON OUTCOMES IN ACUTE INFECTIVE ENDOCARDITIS
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Keywords
Acute infective endocarditis, antibiotic administration, delayed treatment, patient outcome, mortality, Hayatabad Medical Complex.
Abstract
Acute infective endocarditis is a serious condition where there is infection of the endocardial surface of the heart, mostly involving the heart valves. The present study evaluates the effect of delayed antibiotic administration on patient outcomes at Hayatabad Medical Complex, Peshawar. To this end, a retrospective cohort analysis was conducted involving 150 patients diagnosed with AIE from January 2018 to December 2022. Patients were grouped into an early group consisting of those patients who were administered antibiotics within 24 hours and a delayed group consisting of those who received them beyond 24 hours. Delayed presentation was associated with increased mortality, length of hospital stay, and complications such as heart failure and systemic embolization. It is seen from this study that delayed antibiotic administration revealed a significant increase in the mortality rate to 40% as compared to 15.8%, with a prolonged hospital stay of 28.7 days against 21.5 days and with complications like heart failure of 45% versus 22% and systemic embolization in 34% compared to 12%. Future research should aim at identifying the obstacles to timely intervention and hence establish ways through which this can be facilitated with faster institution of intervention.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Shahzeb khan
Post graduate resident, Cardiology, Lady reading hospital, Peshawar
Dr Safi Ullah
Post graduate resident, Cardiology, Peshawar institute of cardiology
Dr Ahmad Amin
Resident Cardiologist, Cardiology Unit, MTI, Mardan Medical Complex
Dr Samandar Khan Babar
Resident physician, Internal medicine, Hayatabad Medical Complex, Peshawar
Dr Akif Ullah Khan
Resident Physician, Internal Medicine, Medical C ward, Hayatabad Medical Complex
Dr Arshad Mehmood
Resident Physcian MBW, General Medicine, Hayatabad Medical Complex, Peshawar
Dr Mohammad Abbas
Medical Officer, Paediatric Oncology, Shoukat Khanum Memorial Hospital and Research Centre
Dr Zubair Ahmad
Resident Physician, Internal Medicine Medical C ward, Hayatabad Medical Complex,Peshawar
Dr Muzzamil Samad
Resident Physician, Internal Medicine, Lady Reading Hospital, Peshawar