COMPARISON OF NEBULIZED FRUSEMIDE WITH NEBULIZED BUDESONIDE ON POST-OPERATIVE SORE THROAT IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA: A COMPARATIVE RANDOMISED, DOUBLE-BLIND PLACEBO-CONTROLLED STUDY.
Main Article Content
Keywords
Airway management, budesonide, cough, furosemide, peri-operative care, sore throat
Abstract
Background: Mucosal damage due to the endotracheal tube cuff can result in sore throat after the surgery. Our present placebo controlled study was planned to compare the effect of nebulised furosemide with nebulised budesonide on post operative sore throat in patients undergoing surgery under general anaesthesia.
Methods: In this randomized prospective study, 120 patients selected and were subjected to three interventions: group B (budesonide), group F (furosemide), and group C (control). Each group had 40 subjects. The primary objective was to determine whether budesonide or furosemide, through ultrasonic nebulization route, can cause any reduction in incidence of post operative sore throat, hoarseness and foreign body sensation.
Results: Out of 120, a total of 90 patients were analyzed. Demographically, all the groups were similar. On comparison to Group C, POST at rest was significantly lower in Group F and Group B at 2,4,6,8,10 hr time points (p < 0.05). On comparison to Group C, post operative hoarseness was significantly lower in Group F and Group B at 2,4,6,8,10 hr time points (p < 0.05). On group wise comparison, Group B had significantly lower incidence of hoarseness than Group F at 6, 8, 10 hr.
Conclusion: Topical use of budesonide or furosemide, through the nebulization route, effectively attenuated the incidence of post operative sore throat when compared to placebo. Either of them can be an alternative for suppression of post operative sore throat.
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Dr Ravneet Kaur Gill
MBBS, MD. Assistant Professor, Dept of Anaesthesia, Dr B R Ambedkar State Institute Of
Medical Sciences, Mohali. Punjab. India
Dr Puja Saxena
MBBS, MD. Associate Professor and Head, Dept of Anaesthesia, Dr B R Ambedkar State Institute Of Medical Sciences, Mohali. Punjab. India
Dr Ashwani Mudgal
MBBS MS, Consultant, Dept of Orthopaedics, Civil Hospital, Ambala Cantt. Haryana. India
Dr Agrawal Kavita Khemchand
Assistant Professor, Dept of General Surgery, Government medical college and Hospital, Chandigarh India