PHYSIOLOGY AND BIOCHEMISTRY OF SERUM VITAMIN A AND INFLAMMATORY MARKERS IN INDIVIDUALS WITH AND WITHOUT CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a prevalent respiratory condition characterized by persistent airflow limitation and chronic inflammation. Nutritional status, particularly serum vitamin A levels, plays a crucial role in COPD pathophysiology, influencing inflammatory responses and disease progression. The objective of this research was to examine the relationship between inflammatory indicators and serum levels of vitamin A among individuals who have and do not have COPD.

Methodology: A cross-sectional study was conducted at the District Head Quarter Mardan, involving 80 clinically stable COPD patients and 80 controls. Participants underwent thorough clinical assessments, including spirometry, chest X-rays, and nutritional evaluations. Vitamin A level in serum and key markers of inflammation such as CRP, TNF-α, and interleukins were measured. Statistical analyses were performed to assess associations and correlations.

Results: COPD patients exhibited lower serum vitamin A levels compared to controls, with a significant elevation in inflammatory markers. The study revealed a bidirectional relationship between vitamin A and inflammation in COPD, emphasizing the potential impact of nutritional status on disease severity.

Conclusion: The findings highlight the intricate relationship between serum vitamin A levels and inflammatory markers in COPD. Lower vitamin A levels in COPD individuals suggest a potential link to heightened inflammation. This study underscores the importance of considering nutritional aspects in COPD management and provides a foundation for future interventions targeting vitamin A.