CARDIOVASCULAR EFFECTS OF CHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ELDERLY PATIENTS WITH DEMENTIA
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Keywords
Dementia, Cardiovascular System, Cholinesterase Inhibitors, Neurology, Elderly
Abstract
Objective: The study aimed to raise awareness of the potential cardiovascular hazards associated with cholinesterase inhibitor therapy in elderly dementia patients.
Background: Cholinesterase inhibitors, which increase levels of the neurotransmitter acetylcholine, are commonly used to treat Alzheimer's disease. These medications aid memory and promote cell-to-cell contact, but they also pose significant cardiac-related risks.
Methods: A bibliographic search utilizing the Boolean operator AND was conducted as part of an integrative literature review. Databases searched included Cholesterol Inhibitors, Dementia, Older people, and the cardiovascular system; an Online Scientific Electronic Library; and an Online Medical Literature Analysis and Retrieval System (MEDLINE).
Results: Six papers were identified and reviewed. The findings highlighted various cardiovascular issues linked to cholinesterase inhibitor use, including arrhythmias, stroke, systemic arterial hypertension, syncope, postural hypotension, and bradycardia.
Conclusions: The review underscores the necessity for continuous evaluation of patients undergoing cholinesterase inhibitor therapy. Adjustments in treatment should be made considering the patient's medical history, current health status, and evolving conditions to mitigate cardiovascular risks.
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Dr. Avrina Kartika Ririe MD
Staff, Department of Brain & Heart Center, Mohammad Hoesin General Hospital, Indonesia
Mandeep Kaur
MD, Department Internal Medicine, HCA Capital Regional Med Center 2626 Capital Medical Blvd, Tallahassee, FL 32308, USA
Araj Siddiqui
Medical Officer, Accident and Emergency Department, Bahria International Hospital, Pakistan
Ellen Y. Huang
MD, Pre-Clinical MD Student, Caribbean Medical University
Maudlyn O. Etekochay
MPH, MBA, Clinical QI Consultant, Inova Hospital, Department of Quality Improvement, USA
Dr. Alexander Edo Tondas MD
Head of the Department, Department of Brain & Heart Center, Mohammad Hoesin General Hospital, Indonesia
Venkata Anirudh Chunchu
Medical Student, Avalon University School of Medicine, Curacao
Tariq Rafique
Assistant Professor Dadabhoy Institute of Higher Education, Karachi, Pakistan