EVALUATION OF CONTRAST SENSITIVITY IN DETECTING SUBCLINICAL OPTIC NEUROPATHY FOLLOWING ETHAMBUTOL THERAPY

Main Article Content

Dr. Sarbori Saha
Dr. Diki Ongmu Shenga

Keywords

..

Abstract

Ethambutol, widely used in the treatment of tuberculosis, is associated with the risk of optic neuropathy, potentially leading to irreversible vision loss if not detected early. Subclinical optic toxic neuropathy, characterized by early changes in optic function without overt symptoms, can be challenging to diagnose using standard ophthalmic tests. Contrast sensitivity measurement has emerged as a sensitive tool for detecting these early changes. This study aims to evaluate the effectiveness of contrast sensitivity testing in identifying subclinical optic neuropathy in patients undergoing ethambutol therapy, providing critical insights into early intervention and management

Abstract 42 | Pdf Downloads 10

References

1. Narang RK, Varma BMD. Ocular toxicity of ethambutol (A clinical study). Ind J Ophthalmol.1979;1:37-40
2. Polak BCP, Leys M, vanLith GHM.Blue – yellow color vision changes as early symptos of ethambutol oculotoxicity. Ophthamologica,Basel.1985;191:223-226 3.Chatterji VKK, Buchanan DR, Friedman AJ,green M.Ocular toxicity following ethambutol in standard dosage.Br j Dis Chest.1986,80:288-291
4. Sivakumaran P, Harrison AC , Marschner J.Martin P.Ocular toxicity from ethambutol: A review of four cases and recommended precautions. N Z Med J. 1998; 111(1077): 428-430
5. Saraux H, Bechetpille A,Nou B. Optic Neuritis caused by ethambutol.Nouv Presse Med 1973;2:2692
6. Elliot DB, Sanderson K , Conkey A. The reliability of Pelli- Robson contrast sensitivity chart.Ophthal Physiol Opt. 1990;10:21-24
7. Salmon JF, Carmichael TR, Welsh NH. Use of contrast sensitivity measurement in the detection of sub clinical ethambutol toxic optic neuropathy.Br. J Ophthalmol.1987;71:192-196