TO STUDY THE EFFECT OF VITAMIN-C AS AN ADDITIONAL THERAPY WITH ANTIDIABETIC DRUGS IN TYPE-2 DIABETES MELLITUS PATIENTS
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Keywords
Vitamin C, Antidiabetic drug, Diabetes mellitus, Glimepiride, Voglibose
Abstract
INTRODUCTION: Diabetes mellitus is a metabolic condition characterised by hyperglycemia, which is commonly coupled with oxidative stress. Aside from hyperglycemia, oxidative stress plays a significant role in diabetes and its consequences, including diabetic neuropathy, nephropathy, and retinopathy. Reducing oxidative stress may improve the outcome of diabetes patients. The current study was designed to investigate the effect of oral hypoglycemic agents (OHA) and vitamin C on oxidative stress, lipid profile, and glycemic control.
AIM AND OBJECTIVE: To study the effect of vitamin-c as an additional therapy with antidiabetic drugs in type-2 diabetes mellitus patients
MATERIAL AND METHODS: This was a prospective study carried out in the Department of Pharmacology for a period of 12 months i.e, April 2023 to April 2024 at a tertiary care Centre. A total of 100 type-II diabetes mellitus patients were studied and divided into four groups, Group-A (Glimepiride), Group-B (Glimepiride + Vitamin-C), Group-C (Metformin + Voglibose) and Group-D (Metformin+ Voglibose+ Vitamin-C). Glycemic control, lipid profile and oxidative stress were compared before and after 3 months of treatment in all the 4 groups. The Data was analyzed By using SPSS Software.
RESULTS: In the present study after three months, all the four groups had significant glycemic control (p<0.001), but only Groups B and D experienced significant reductions in oxidative stress (p<0.001). Groups B, C, and D showed significantly improved lipid control.
CONCLUSION: Vitamin-C supplementation in conjunction with OHA therapy improves glycemic control and lipid levels, and as an antioxidant, it decreases oxidative stress in diabetes mellitus patients.
References
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Dr. Stuti Singh
Assistant Professor, Department of Pharmacology, Uma Nath Singh Autonomous State Medical College, Jaunpur, India.
Dr. Palash Ratna
Assistant Professor, Department of Pharmacology, Uma Nath Singh Autonomous State Medical College, Jaunpur, India.
Dr. Luv Arya
Senior Resident, Department of Pharmacology, Uma Nath Singh Autonomous State Medical College, Jaunpur, India.
Dr. Nashra Afaq
Research Associate, Department of Microbiology and Central Research Laboratory, Rama Medical College Hospital and Research Centre, Uttar Pradesh, India.
Dr. Nusrat Nabi
Associate Professor, Department of Pharmacology, HIMSR & HAHC Hospital, Jamia Hamdard, New Delhi, India.
Dr. Firoza Bano
Associate Professor, Department of Community Medicine, Al-Falah School of Medical Sciences and Research Centre, Faridabad, Haryana.
Dr.Saif Anees
Associate Professor, Department of Community Medicine, Government Medical College, Kannauj, India.