POSTOPERATIVE OUTCOMES IN CHILDREN WITH TYPHOID ILEAL PERFORATION: PRIMARY REPAIR VERSUS ILEOSTOMY

Main Article Content

Dr Majid Arshad
Dr Anum Fatima
Dr Muhammad Imran
Dr Rahmat Ali Khan
Dr Mujahid Ullah

Keywords

Typhoid, ileal perforation, primary repair, ileostomy

Abstract

Objective


To evaluate and contrast the postoperative outcomes of primary repair versus ileostomy in pediatric patients with typhoid perforation.


Methodology


This comparative study, conducted in pediatric surgery unit, DHQ Teaching Hospital Timergara Lower Dir KPK, Pakisan.in the duration from December 2022 to May 2024, included 70 patients aged 3 to 18 years diagnosed with typhoid perforation. After ethical approval and informed consent from guardians, patients were randomly divided into two groups: Group A (35 patients) underwent primary repair, while Group B (35 patients) received an ileostomy. Preoperative administration of broad-spectrum antibiotics was standard for all patients. Postoperative outcomes, including complications and mortality rates, were documented and analyzed using SPSS version 20.0, with categorical variables compared via the chi-square test to identify the more effective surgical intervention.


Results


This study compared outcomes of primary repair (Group A) versus ileostomy (Group B) in 70 pediatric patients with typhoid ileal perforation. Group A had a mean age of 10.5 years and Group B, 11.8 years, with a slightly higher proportion of males in both groups. Most patients had unsatisfactory socio-economic conditions and rural residency. Symptoms included abdominal pain (91%), pyrexia (87%), abdominal distention (81%), constipation (59%), vomiting (53%), and diarrhea (21%). Local complications were significantly higher in the ileostomy group, with notable differences in wound dehiscence, infection, and skin excoriation. Systemic complications like electrolyte disturbance and weight loss were also more frequent in the ileostomy group. Mortality was higher in the ileostomy group but not statistically significant. Primary repair demonstrated fewer complications and better outcomes, indicating it as the more effective treatment for pediatric typhoid perforation.


Conclusion


Our study favors primary repair over ileostomy for typhoid ileal perforation, showing fewer postoperative complications like wound issues and electrolyte disturbances. While both procedures had similar mortality rates, primary repair appears safer and more effective, especially for patients without significant health complications. This draw attention to the importance of choosing primary repair when managing this condition to improve surgical outcomes and patient recovery.

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References

1. Bhandari J, Thada PK, Hashmi MF, et al. Typhoid Fever. [Updated 2024 Apr 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557513/
2. Khalaf YJ, Alagha R. Fatal Complications of Extensive Drug-Resistant Typhoid Fever: A Case Report. Cureus. 2023 Jun 20;15(6):e40672. doi: 10.7759/cureus.40672. PMID: 37485196; PMCID: PMC10357127.
3. Contini S. Typhoid intestinal perforation in developing countries: Still unavoidable deaths? World J Gastroenterol. 2017 Mar 21;23(11):1925-1931. doi: 10.3748/wjg.v23.i11.1925. PMID: 28373758; PMCID: PMC5360633.
4. Parini D, Bondurri A, Ferrara F, Rizzo G, Pata F, Veltri M, Forni C, Coccolini F, Biffl WL, Sartelli M, Kluger Y, Ansaloni L, Moore E, Catena F, Danelli P; Multidisciplinary Italian Study group for STOmas (MISSTO). Surgical management of ostomy complications: a MISSTO-WSES mapping review. World J Emerg Surg. 2023 Oct 10;18(1):48. doi: 10.1186/s13017-023-00516-5. PMID: 37817218; PMCID: PMC10563348.
5. Bundalian R Jr, Valenzuela M, Tiongco RE. Achieving accurate laboratory diagnosis of typhoid fever: a review and meta-analysis of TUBEX® TF clinical performance. Pathog Glob Health. 2019 Oct;113(7):297-308. doi: 10.1080/20477724.2019.1695081. Epub 2019 Nov 28. PMID: 31778097; PMCID: PMC7006692.
6. Hafner J, Tuma F, Hoilat GJ, et al. Intestinal Perforation. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538191/
7. Njarekkattuvalappil SK, Thomas M, Kapil A, Saigal K, Ray P, Anandan S, Nagaraj S, Shastri J, Perumal SPB, Jinka DR, Thankaraj S, Ismavel V, Zachariah P, Singh A, Gupta M, Ebenezer SE, Thomas MS, Ghosh D, Kataria K, Senger M, Balasubramanian S, Kang G, John J. Ileal Perforation and Enteric Fever: Implications for Burden of Disease Estimation. J Infect Dis. 2021 Nov 23;224(Supple 5):S522-S528. doi: 10.1093/infdis/jiab258. PMID: 35238354; PMCID: PMC8914860.
8. Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018 Jul 7;392(10141):75-87. doi: 10.1016/S0140-6736(18)30696-2.
9. Sharma A, Sharma R, Sharma S, Sharma A, Soni D. Typhoid intestinal perforation: 24 perforations in one patient. Ann Med Health Sci Res. 2013 Nov;3(Suppl 1):S41-3. doi: 10.4103/2141-9248.121220. PMID: 24349848; PMCID: PMC3853607.
10. De Waele JJ, Coccolini F, Lagunes L, Maseda E, Rausei S, Rubio-Perez I, Theodorakopoulou M, Arvanti K. Optimized Treatment of Nosocomial Peritonitis. Antibiotics (Basel). 2023 Dec 8;12(12):1711. doi: 10.3390/antibiotics12121711. PMID: 38136745; PMCID: PMC10740749.
11. Mittal S, Singh H, Munghate A, Singh G, Garg A, Sharma J. A comparative study between the outcome of primary repair versus loop ileostomy in ileal perforation. Surg Res Pract 2014;2014: 729018
12. Mishra M, Singh P, Tripathi A. Typhoid ileal perforation: comparative study of ileostomy versus primary ileal repair andassociated morbidity and mortality. Int J Surg 2018;5(9):3129-3133.doi:10.18203/2349-2902.isj20183735
13. Babu TN, Harika R, Chakravarthy DS, Akkidas S. Acomparative studybetween the outcome of primary repair versus ileostomy in ileal perforation: our institutional experience. J Med Sci Clin Res. 2019;7(9):327-331. doi:10.18535/jmscr/v7i9.57
14. Gul S, Parveen S, Iqbal M, Ahmed T, Khan I, Nawaz A. Typhoid Ileal Perforation: Comparative Study of Ileostomy Versus Primary Repair and associated Morbidity and Mortality. Pak Armed Forces Med J [Internet]. 2023 Apr. 17 [cited 2024 Jun. 19];73(2):374-77
15. K. AP, A.C. A, H.K. R, H.C. Sn, K.S G, K.R. S.Mortality in Typhoid Intestinal Perforation–A Declining Trend.J Clin of Diagn Res.2013; 7(9):1946-1948.