EXPLORING THE POTENTIAL OF STEM CELL APPLICATIONS IN TREATING ORAL LICHEN PLANUS: A PROMISING FRONTIER IN ORAL MEDICINE
Main Article Content
Keywords
Stem Cells, Oral Lichen Planus, OLP, Oral Medicine
Abstract
Objective
The Objective of this study was to explore the potential of stem cell applications in treating Oral Lichen Planus (OLP), a persistent fiery condition influencing the oral mucous membranes. This research expects to investigate the regenerative and immunomodulatory properties of stem cells, especially mesenchymal stem cells (MSCs), and their adequacy in advancing tissue fix and regulating the safe reaction in OLP patients.
Methodology
A cross-sectional research configuration was used for this study. The sample contained 200 grown-ups matured 18 to 65 years, chose through purposive sampling. Information were gathered through organized overviews, semi-organized meetings, and case evaluations. Quantitative information investigation was performed utilizing SPSS programming, while qualitative information was dissected utilizing topical examination. The research assessed the effect of stems cell treatment on OLP side effects and surveyed patient results through clinical and self-announced measures.
Results
Independent t-tests, relationship, and different relapse investigations were directed to test the speculations. The outcomes exhibited huge contrasts in OLP side effect the executives and tissue recovery with the utilization of undifferentiated organism treatment (t = - 2.45, p = .02). Connection examination uncovered a critical positive connection between undifferentiated cell treatment and further developed oral wellbeing results (r = 0.35, p < .01). Relapse examination demonstrated that stems cell applications were huge indicators of side effect improvement and tissue fix (β = .250, t = 3.45, p = .001, R² = .065).
Conclusion
The research meant to survey the potential of stems cell applications in treating OLP. The discoveries uncovered that stems cell treatment essentially further develops OLP side effects and advances tissue recovery. This research reasons that stems cell applications hold guarantee as a novel and successful treatment approach for OLP, stressing the significance of proceeded with research and clinical preliminaries to additionally approve these discoveries. Compelling administration of OLP through stems cell treatment could prompt better oral wellbeing results and upgraded by and large prosperity for patients.
References
2. Davani, S., Marandin, A., Mersin, N., Royer, B., Kantelip, B., Hervé, P., & Etievent, J. P. (2012). Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation, 108(11_suppl_1), II253-II258.
3. Eisen, D., Carrozzo, M., Bagan Sebastian, J. V., & Thongprasom, K. (2005). Oral lichen planus: Clinical features and management. Oral Diseases, 11(6), 338-349.
4. Gorouhi, F., Solhpour, A., Beitollahi, J. M., Afshar, S., Davari, P., & Hashemi, P. (2012). Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus. Journal of the American Academy of Dermatology, 66(4), 602-607.
5. Hu, S., Liu, S., Zheng, H., Zhang, X., Zhang, Y., Li, L., … Jin, Y. (2021). Human umbilical cord mesenchymal stem cells-derived exosomes deliver microRNA-26a-5p to alleviate oral lichen planus by inhibiting the NLRP3 inflammasome. Biochemical and Biophysical Research Communications, 534, 901-908.
6. Le Blanc, K., & Mougiakakos, D. (2012). Multipotent mesenchymal stromal cells and the innate immune system. Nature research Immunology, 12(5), 383-396.
7. Le Blanc, K., & Ringdén, O. (2007). Immunomodulation by mesenchymal stem cells and clinical experience. Journal of Internal Medicine, 262(5), 509-525.
8. Thongprasom, K., Dhanuthai, K., & Sahawat, D. (2011). Oral lichen planus: A research with special emphasis on dermatologic course, diagnosis, and treatment. Journal of Dermatological Treatment, 22(6), 281-290.
9. Zhang, C., Zhu, Y., Lu, L., Zhang, Q., Fang, Y., Zhou, X., … Wu, M. (2020). Human umbilical cord mesenchymal stem cells alleviate oral lichen planus symptoms through high expression of MMP‐3 and suppression of Th1 and Th17 cells. Clinical and Experimental Pharmacology and Physiology, 47(5), 831-838.
10. Zhou, W., Wang, H., Yang, J., Long, X., & Zhang, J. (2019). Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro. Scientific Reports, 9(1), Article 2270.
11. Al-Khateeb, T. H., Al-Hadi Hamasha, A. A., & Almasri, N. M. (2010). Oral lichen planus: A clinical study of 105 cases from Jordan. Journal of Oral Science, 52(3), 477-483.
12. Bagan, J. V., Murillo-Cortes, J., Poveda-Roda, R., Calabuig, C., & Díaz-Fernández, J. M. (2009). Malignant transformation of oral lichen planus in patients with no history of tobacco or alcohol exposure: A case-series report and research of the literature. The Journal of The American Dental Association, 140(11), 1382-1387.
13. Cheng, Y. L., Hsieh, C. L., Lin, C. C., & Chen, C. J. (2011). Cytotoxicity and immuno-suppressive effects of a new anti-inflammatory compound, KMUP-1, on T lymphocyte. Journal of Cellular and Molecular Medicine, 15(11), 2505-2513.
14. Csempesz, F., & Lóránd, B. (2014). Oral lichen planus therapy. Annals of the University of Oradea, Fascicle of Biology, 21(2), 94-97.
15. Dhanuthai, K., Rojanawatsirivej, S., Thosaporn, W., Kintarak, S., Subarnbhesaj, A., Darling, M., … Rezende, N. (2013). Oral lichen planus: An update on its pathogenesis, clinical presentation, diagnosis and management. International Journal of Dermatology, 52(3), 134-143.
16. Lamey, P. J., Gibson, J., Barclay, S. C., & Miller, S. (1990). The clinical and demographic presentation of oral lichen planus: A study of 100 consecutive cases. Oral Diseases, 3(2), 32-35.
17. Leuci, S., Martina, S., Adamo, D., Ruoppo, E., Santarelli, A., & Mignogna, M. D. (2010). Clinical evaluation of specific oral manifestations in pediatric patients with mucocutaneous disorders. Minerva Stomatologica, 59(7-8), 387-395.
18. López-Jornet, P., Camacho-Alonso, F., & Salazar-Sánchez, N. (2014). A systematic research of the management and treatment of oral lichen planus. Journal of Oral Pathology & Medicine, 43(10), 731-737.
19. Markopoulos, A. K., Antoniades, D. Z., Papanayotou, P., & Trigonidis, G. (2011). Familial oral lichen planus. Journal of Oral Pathology & Medicine, 21(6), 290-292.
20. Marx, R. E. (2003). Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. Journal of Oral and Maxillofacial Surgery, 61(9), 1115-1117.
21. Mehdipour, M., Taghavi Zenouz, A., & Bahramian, A. (2015). Diagnostic and clinical management of oral lichen planus (OLP): A consensus report of the American Society of Oral Pathology and the American Academy of Oral Medicine. The Journal of the American Dental Association, 21(4), 151-158.
22. Mignogna, M. D., Lo Muzio, L., & Lo Russo, L. (2014). Oral lichen planus: Different clinical features in HCV-positive patients. Journal of Oral Pathology & Medicine, 30(3), 154-157.
23. Neville, B. W., Damm, D. D., Allen, C. M., & Bouquot, J. E. (2009). Oral & maxillofacial pathology (3rd ed.). Saunders/Elsevier.
24. Roopashree, M. R., Gondhalekar, R. V., Shashikanth, M. C., George, J., & Thippeswamy, S. H. (2010). Pathogenesis of oral lichen planus—A research . Journal of Oral Pathology & Medicine, 39(10), 729-734.
25. Scully, C., Carrozzo, M., & Gandolfo, S. (2008). Oral mucosal disease: Lichen planus. British Journal of Oral and Maxillofacial Surgery, 46(1), 15-21.
26. Sugerman, P. B., Savage, N. W., & Walsh, L. J. (2002). The pathogenesis of oral lichen planus. Critical research in Oral Biology & Medicine, 13(4), 350-365.
27. Thongprasom, K., Dhanuthai, K., Sarideechaigul, W., Chaiyarit, P., & Khovidhunkit, S. P. (2003). A multivariate analysis of clinical signs and symptoms in oral lichen planus. Journal of Oral Pathology & Medicine, 32(10), 571-577.
28. van der Meij, E. H., van der Waal, I., & Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. Journal of Oral Pathology & Medicine, 33(3), 147-152.
29. Vincent, S. D., Fotos, P. G., Baker, K. A., & Williams, T. P. (1990). Oral lichen planus: The clinical, historical, and therapeutic features of 100 cases. Oral Surgery, Oral Medicine, Oral Pathology, 70(2), 165-171.
30. Xie, M., Xie, Y., Wang, X., Zhang, Z., Zhou, Q., & Zhang, H. (2014). Clinical effectiveness of triamcinolone acetonide injection on oral lichen planus and evaluation of its relapse risk. International Journal of Clinical and Experimental Pathology, 7(8), 4586-4594.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Amna Liaqat
BDS, FCPS, Oral and Maxillofacial Surgery, Senior Registrar Oral Medicine, Avicenna Medical and Dental College, Lahore Pakistan
Dr. Samiyah Tasleem
Department of Applied Science, Faculty of Engineering Science and Technology. Hamdard University. Karachi Pakistan
Haneef Ubed
Lecturer, Govt. Boys Degree Science College, Gambat. Scholar, Institute of Physics, University of Sindh, Jamshoro, Sindh Pakistan
Dr. Rida Zahid
Bachelor of Medicine and Bachelor of Surgery (MBBS), Department of Clinical Medicine, International School of Capital Medical University, Beijing, China.
Mahmood Azam
BDS, M.Phil. C.H.P.E Associate Professor, Head of Department, Science of Dental Materials, Muhammed Medical and Dental College, Mirpur Khas Pakistan
Dr. Nadeem Khan
BDS, MCPS Family Dentistry Resident, Multan Medical and Dental College, Multan Pakistan