A COMPREHENSIVE REVIEW ON FAST DISSOLVING ORAL FILMS: A RECENT ADVANCEMENT IN DRUG DELIVERY TECHNOLOGY
Main Article Content
Keywords
Oral fast dissolving films (OFDF), Buccal drug delivery, Novel Drug Delivery System, Pharmaceutical technology
Abstract
Oral fast dissolving films (OFDF) present an innovative approach to improving patient compliance with medications through their rapid dissolution and ease of administration, requiring no water or chewing. This drug delivery system, which utilizes a thin film placed in the mouth, proves highly effective. These films quickly dissolve or disintegrate within seconds once in the oral cavity, eliminating the need for water. They can be formulated with a variety of medications, including analgesics, antihistamines, asthma therapies, antipsychotics, antiemetics, cardiovascular drugs, treatments for erectile dysfunction etc. This technology provides a convenient method of medication delivery, benefiting not only specific groups such as children, the elderly, bedridden patients, and individuals with mental illnesses, but also the general population. Several production methods exist for these oral films, with the buccal cavity being a primary site of application. The buccal cavity, located in the mouth, features a mucosal layer that facilitates rapid drug distribution and absorption into the body. This review thoroughly examines the preparation techniques for oral films, the selection of appropriate polymers for their formulation, the technologies involved, assessment criteria, and the various practical applications of this drug delivery system.
References
2. A. Zachary Flake, Robert D Scalley and Austin G Bailey, Practical Selection of Antiemetics, American family physician.69(5);2004:1169-74.
3. A. Arunachalam, Karthikeyan M, Ashutosh Kumar S, Kishore, Fast dissolving drug delivery system a review, Journal of Global Trends in Pharmaceutical Sciences. 1(1); 2010:92-11.
4. A.R. Patel, Dharmendra S, Prajapati, Jignyasha A, Raval, Fast Dissolving Films (FDFS) As A Newer Venture in Fast Dissolving Dosage Forms, Int. J. Drug Dev. & Res.2(2);2010:232-246.
5. Apoorva Mahajan, Neha Chhabra, Geeta Aggarwal, Formulation and characterization of fast dissolving buccal films, Der Pharmacia Letter.3(1);2011:152-165.
6. Arun Arya, Amrish Chandra, Vijay Sharma and Kamla Pathak. Fast Dissolving Oral Films: An Innovative Drug Delivery System and Dosage Form, International Journal of Chem Tech Research. 2(1);2010: 576-583.
7. Avani Amin and Renuka Mishra, Optimization and Characterization of Rapidly Dissolving Films of Cetirizine Hydrochloride Using Cyclodextrins For Taste Masking, International Journal of PharmTech Research. ,5(2):2013,536- 552.
8. B. Suresh, Halloran D, James L, Quick dissolving films: A Novel Approach to drug delivery, Drug delivery. Drug development technology. Pp; 2006: 1-7.
9. Basani Gavaskar, Subash Vijaya Kumar, Guru Sharan, Madhusudhan Rao Y, Overview on fast dissolving films, Int J Pharmacy and Pharm Sci. 2(3);2010:0975-1491.
10. Bhupinder Bhyan, Sarita J, Manadeep Kaur, Harmanpreet Singh, Orally fast dissolving films Innovations in formulation and technology. Int. Journal of Pharm Sci Rev & Res.9; 2011:2-9.
11. Bhupinder Bhyan, Sarita J, Manadeep Kaur, Harmanpreet Singh, Orally fast dissolving films: Innovations in formulation and technology. Int. Journal of Pharm Sci Rev & Res.9; 2011:2-9.
12. Buchi N. Nalluri, B. Sravani, V Saisri Anusha, R. Sribramhini, K.M. Maheswari., Development and evaluation of mouth dissolving films of Sumatriptan succinate for better therapeutic efficacy, Journal of applied pharmaceutical science.3(8);2013:161-166.
13. CH. Sumitha, Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid disintegrating films.1(2);2009:24-27.
14. Chapdelaine A.H, Zyck DJ, Dzija MR, Edible Film Formulations Containing Maltodextrin, US Patent. May 25, US Patent, 6740332; 2004:32.
15. Deepak Heer, Geeta Aggarwal and S. L. Hari Kumari, recent trends of fast dissolving drug delivery system - an overview of formulation technology, Pharmacophore. 2013, 4 (1):1-9.
16. Deepthi A, Venkateshwara Reddy. B, Navaneetha K, Formulation and evaluation of fast dissolving oral films of Zolmitriptan. American journal of advanced drug delivery.2014:153-163.
17. Dhere P.M, Patwekar S.L. review on preparation and evaluation of oral disintegrating films, IJPT. 3(4); 2011:1572- 1585.
18. Doaa Ahmed El-Setouchy, Nevine Shawky Abd El-Malak, Formulation of a Novel Tianeptine Sodium Orodispersible Film. 11(3):2010.
19. Frey. Film strips and pharmaceuticals. Pharmaceutical Manufacturing and Packaging Resource. 4; 2006: 92-93.
20. Gerad J Tortora; Bryan Derrickson: Principles of anatomy and physiology, 11thedition.
21. Gsnayub Rasool, Guidance for industry: Orally disintegrating tablets, center for drug Evaluation and Research (CDER), USFDA),International journal of innovative pharmaceutical sciences and research.2;2008:688-702.
22. Harsha Kathpalia, Bhairavi Sule, Aasavari Gupte, Development and Evaluation of Orally Disintegrating Film of Tramadol Hydrochloride, Asian Journal of Biomedical and Pharmaceutical Sciences.3(24);2013:27-32.
23. Hiroyoshi Shimoda, Kazumi Taniguchi, M.Nishimura, Katsuhiko Matsuura, Tadao Tsukioka, Hirotaka Yamashita, Naoki Inagaki, Kazuyuki Hirano, Mayumi Yamamoto, Yasutomi Kinosada and Yoshinori Itoh. Preparation of a fast dissolving oral thin film containing dexamethasone a possible application to antiemesis during cancer chemotherapy, Eur J Pharm Biopharma PMID.2009:19735731.
24. Hornby, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW, Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol, Appl Environ Microbiol. 67(7); 2001:2982-92.
25. J. Aggarwal and G. Singh, Fast Dissolving Film A Novel Approach to oral drug delivery, International Research Journal of Pharmacy.2;2011:69-74.
26. Jui Trivedi, Rajavi Patel, Dron Modi, Upendra Patel, Ragin shah, Mouth dissolving film: a new era in pharma field as a conventional dosage form: a review, IJPRBS, 2014;3(1): 149- 161.
27. Kai Bin Liew, Yvonne Tze Fung Tan, Kok Khiang Peh, Characterization of oral disintegrating film containing Donepezil for Alzheimer disease, American Association of Pharmaceutical Scientists. 13; 2011:134-142.
28. Kaur Mandeep, Fast dissolving films an innovative drug delivery system. IJPRR. 2(1); (2013):14-24.
29. Kulkarni P K, Dixit M, Gunashekara K, Shahnawaz A, Kulkarni A; Singh MN, Formulation and evaluation of mouth dissolving film containing Rofecoxib, International research journal of pharmacy. 2(3); 2011:273-278.
30. LME Mc Indoe; RC Rowe; Pj Sheskey; SC Owen; Hand book of Pharmaceutical Excipients, Pharmaceutical Press, London, 2006.
31. LME Mc Indoe; RC Rowe; Pj Sheskey; SC Owen; Hand- book of Pharmaceutical-Excipients, Pharmaceutical Press, London, 2006.
32. M.C. Gohel, Parikh R.K, Nagori S.A, Fabrication of Modified Release Tablet Formulation of Metoprolol Succinate using Hydroxypropyl Methylcellulose and Xanthan Gum, AAPS Pharm. Sci. Tech. 10(1);2009: 62-68.
33. MD.Nehal Siddiqui, A novel approach in oral fast dissolving drug delivery system and their patents, advances in biological research. 5(6); 2011:291-303.
34. Minami M, Nakagawa T, Seki T, Onogi T, Aoki Y, Katao Y, Katsumata S, Satoh M. A single residue, Lys108, of the delta- opioid receptor prevents the mu-opioid-selective ligand [D-Ala2,N-MePhe4,Gly-ol5]enkephalin from binding to the delta- opioid receptor. Mol Pharmacol. 50(5); 1996:1413-22.
35. Mital S. Panchal, Hiren Patel, Aarti Bagada, K. R. Vadalia, Formulation and Evaluation of Mouth Dissolving Film of Ropinirole Hydrochloride by Using Pullulan Polymers. IJPRAS.3; 012: 60-72.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Khemani Purva
Modern Institute of Pharmaceutical Sciences, Modern Campus,Gram Alwasa, Sanwer Rd, behind Rewti Range, Indore, Madhya Pradesh 453111
Joshi, Ankur
Modern Institute of Pharmaceutical Sciences, Modern Campus,Gram Alwasa, Sanwer Rd, behind Rewti Range, Indore, Madhya Pradesh 453111
Malviya Sapna
Modern Institute of Pharmaceutical Sciences, Modern Campus,Gram Alwasa, Sanwer Rd, behind Rewti Range, Indore, Madhya Pradesh
Kharia Anil
Modern Institute of Pharmaceutical Sciences, Modern Campus,Gram Alwasa, Sanwer Rd, behind Rewti Range, Indore, Madhya Pradesh 453111