Main Article Content
osteoporosis, bone metabolism, bone mineral density, bisphosphonate, teriparatide, alendronate, zoledronate, risedronate, clodronate, hormonal therapy, TSEC, denosumab, romosozumab, strontium ranelate, combination therapy, sequential therapy
In the last decade of the 20th century, several molecules have been developed and proved to be effective in achieving the true goal of any antiosteoporotic drug: fracture prevention.
In this article, we considered the most commonly prescribed antiresorptive drugs (hormonal therapy, bisphosphonates, and denosumab), the anabolic agents (teriparatide), the dual-action drugs (romosozumab), and the drugs characterized by an unclear mechanism of action (strontium ranelate) to provide physicians with useful insights for their clinical practice. We discussed the main criteria for the appropriate choice selection and management of each treatment. Finally, we addressed the current controversies related to treatment discontinuation, sequential, and combination therapy.
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