THE ROLE OF MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) IN THE SPECTRUM OF COVID-19 COMPLICATIONS

Main Article Content

Danyal Mehmood. Dr Zubair Ahmed Hamza Maqbool Dr Aniba Tabassum Dr Irslan hussain khan Bhu deesah phagwati. Dr Aqsa hassan Dr Afifa Munir Ahmad Kashif Lodhi

Keywords

COVID-19 complications, Multisystem Inflammatory Syndrome in Children (MIS-C), pediatric populations, hyperinflammatory response, epidemiology, pathogenic mechanisms, public health, diagnosis, management.

Abstract

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has led to a range of clinical manifestations in both adults and children. Among the various complications related with COVID-19, Multisystem Inflammatory Syndrome in Children (MIS-C) has occurred as a distinct and concerning condition. MIS-C is considered by the hyperinflammatory response and multi-organ involvement, affecting pediatric populations who were previously asymptomatic or had mild COVID-19 symptoms. Understanding role of MIS-C within the spectrum of COVID-19 complications is crucial for healthcare providers, researchers, and policymakers.


Aim: This study aims to comprehensively investigate the clinical features, epidemiology, and potential mechanisms underlying MIS-C and its association with COVID-19. By analyzing available data, we seek to offer perceptions into character of MIS-C in broader context of COVID-19 complications, its impact on affected children, and the implications for public health approaches.


Methods: The study is conducted in Children hospital Lahore. A systematic review and meta-analysis were led to measure available literature on MIS-C in children with COVID-19. PubMed, Scopus, and other relevant databases were searched for researches published from beginning of the COVID-19 pandemic to present. Eligible studies were screened, and data were extracted and analyzed to identify common clinical presentations, demographic characteristics, and potential risk factors associated with MIS-C. Statistical analysis and qualitative synthesis were performed to derive meaningful insights.


Results: Our analysis revealed that MIS-C is very occasional but serious problem of COVID-19 in children, typically occurring a few weeks after the acute phase of the viral infection. Clinical manifestations of MIS-C comprise fever, gastrointestinal signs, cardiovascular abnormalities, and hyperinflammatory markers. Epidemiological data indicate that MIS-C is more prevalent among specific age groups and ethnic backgrounds. Possible pathogenic mechanisms involve an exaggerated immune response, potentially triggered by viral antigens. Timely recognition and appropriate management are essential to improve outcomes in affected children.


Conclusion: Multisystem Inflammatory Syndrome in Children (MIS-C) is an important entity within the spectrum of COVID-19 complications, affecting pediatric populations. It presents as a severe and systemic hyperinflammatory response and poses significant health risks to affected children. Early recognition, appropriate diagnosis, and management are crucial in mitigating the impact of MIS-C. Public health measures should consider the potential for MIS-C when planning COVID-19 mitigation strategies. Further research is required to fully recognize pathophysiology of MIS-C and to enhance targeted interventions to reduce the associated morbidity and mortality.

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