PLACENTAL HISTO-MORPHOMETRIC CHANGES IN PREECLAMPSIA AND ITS ASSOCIATION WITH BETATROPHIN
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Keywords
Betatrophin, Placenta, Pre-eclampsia, Pregnancy Induced Hypertension
Abstract
Preeclampsia is one of hypertensive disorders in pregnancy that occurs after the 20th weeks of pregnancy along with proteinuria. It threatens maternal and child health and has worldwide prevalence of about 3–8%. This cross-sectional study included 90 cases among them 45 women were diagnosed with preeclampsia and 45 normal pregnant women was carried out from December 2021 to November 2022 at department of anatomy in collaboration with department of gyneacology and obstetric, Liaquat University of Medical and Health Sciences, Jamshoro after getting ethical approval. Placental histological changes were matched for betatrophin levels. Their age, gravidity, gestational age, socioeconomic status, and mode of delivery were recorded. The mean betatrophin level in control 1.66 ± 0.10 and in pre-eclampsia 1.71± 0.06. Plasma betatrophin levels were found significant in PE than in control groups (p<0.008). Placental morphological and morphometric parameters were significant in PE than control group. All gross and microscopic parameters of placenta were altered in preeclampsia along with plasma elevated levels of betatrophin. These findings may bring out betatrophin as a new marker to predict, prevent, and treat pre-eclampsia.
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Dr. Rabia Bughio
Lecturer, Department of Anatomy, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan, drraya786@gmail.com
Dr. Samreen Memon
Professor / Chairperson, Department of Anatomy, Liaquat University of medical and health sciences, Jamshoro, Pakistan, samreen.memon@lumhs.edu.pk
Dr. Farhana Rajper
Associate professor, Department of Anatomy, Liaquat University of medical and health sciences, Jamshoro, Pakistan, farhana.rajper@lumhs.edu.pk
Dr. Pushpa Goswami
Professor, Department of Anatomy, Liaquat University of medical and health sciences, Jamshoro, Pakistan, pushparamesh1998@gmail.com
Dr. Khalida Parveen
Lecturer, Department of anatomy, Liaquat University of medical and health sciences, Jamshoro, Pakistan, deparkhalida@gmail.com
Dr. Amber
Assistant Professor, Department of Anatomy, Mekran Medical College, Turbat, Balochistan, Pakistan, amberabdulghani@yahoo.com