IN VIVO ANALGESIC, MUSCLE RELAXANT AND SEDATIVE EVALUATION OF CRUDE EXTRACT OF TAXUS WALLICIANA Zucc.
Main Article Content
Keywords
Taxus Walliciana, analgesic, muscle relaxant, sedation
Abstract
Traditionally, Taxus Walliciana has been used to treat various ailments, including cancer, pain, convulsions, and fever. This study investigated the analgesic, muscle relaxant, and sedative effects of the crude extract of the whole Taxus Walliciana plant. The results showed a significant (p < 0.001) analgesic effect, with 88% attenuation of writhing. However, the extract did not exhibit central analgesic activity in the hot plate model. A short-term muscle relaxant effect was observed, with 33% and 75% efficacy in the traction and inclined plane models, respectively. No sedative effect was noted. In conclusion, the crude extract of Taxus Walliciana demonstrates analgesic and muscle relaxant properties, warranting further investigation into its potential therapeutic applications
References
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25. S. AlOmar, T.; Rauf, A.; Rashid, U.; Sarfaraz, S.; Ayub, K.; Hussain, F.; Almasoud, N.; S. AlOmar, A.; Rehman, G.; Ahmad, Z., Molecular docking, DFT studies, and anti-inflammatory evaluation of peshawaraquinone isolated from Fernandoa adenophylla. Journal of Biomolecular Structure and Dynamics 2023, 1-13.
26. Qayum, M.; Nisar, M.; Shah, M. R.; Adhikari, A.; Kaleem, W. A.; Khan, I.; Khan, N.; Gul, F.; Khan, I. A.; Zia‐ul‐Haq, M. J. P. R., Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. 2012, 26 (4), 552-556.
2. Rauf, A.; AlOmar, T. S.; Sarfaraz, S.; Ayub, K.; Hussain, F.; Rashid, U.; Almasoud, N.; AlOmar, A. S.; Rehman, G.; Ahmad, Z., Density functional theory, molecular docking, In vitro and In vivo anti-inflammatory investigation of lapachol isolated from Fernandoa adenophylla. Heliyon 2023, 9 (12).
3. Rauf, A.; Rashid, U.; Atta, A.; Khan, I.; Shah, Z. A.; Mobeen, B.; Javed, A.; Alomar, T. S.; Almasoud, N.; Naz, S., Antiproliferative Activity of Lignans from Olea ferruginea: In Vitro Evidence Supported by Docking Studies. Frontiers in Bioscience-Landmark 2023, 28 (9), 216.
4. shahab Khan, M.; Ahmad, M.; Tahir, M.; Khan, M. A., In vitro screening of Cichorium intybus, a local medicinal plant for antimicrobial activities. Phytopharmacology Research Journal 2022, 1 (2), 1-10.
5. Hafeez, N., Phytochemical and Biological Studies of Cucurbitaceae: A Mini-Review. Phytopharmacology Research Journal 2024, 3 (1), 13-23.
6. Niaz, M.; Qayyum, H.; Abrar, H.; Jadoon, R.; Ashfaq, S.; e Baseerat, N.; Khan, N.; Bibi, B., Qualitative phytochemical analysis of rhizomes and roots extracts of Bergenia ciliate. Phytopharmacology Research Journal 2023, 2 (3), 22-27.
7. Ahmad, Z.; Rauf, A.; Zhang, H.; Ibrahim, M.; Muhammad, N.; Al-Awthan, Y. S.; Bahattab, O. S., Green synthesis and multifaceted characterization of iron oxide nanoparticles derived from Senna bicapsularis for enhanced in vitro and in vivo biological investigation. Green Processing and Synthesis 2024, 13 (1), 20240001.
8. Muhammad, M. I.; Huma, Z.; Bibi, N.; Shah, S. M. M.; Javed, A.; Ibrahim, M., In vitro Antifungal Activity of Menta Piperita Extract Against Venturia inaequalis. Phytopharmacology Research Journal 2022, 1 (2), 24-37.
9. shahab Khan, M.; Ahmad, M., In vitro antimicrobial activity of Rumex Dentatus L.(Polygonaceae) plant extracts. Phytopharmacology Research Journal 2022, 1 (3), 32-42.
10. Rauf, A.; Muhammad, N.; Khan, A.; Uddin, N.; Atif, M. J. W. A. S. J., Antibacterial and phytotoxic profile of selected Pakistani medicinal plants. 2012, 20 (4), 540-4.
11. Uddin, G.; Rauf, A.; Siddiqui, B. S.; Shah, S. Q. J. M.-E. J. o. S. R., Preliminary comparative phytochemical screening of Diospyros lotus Stewart. 2011, 10 (1), 78-81.
12. Ikan, R., The origin and the nature of natural products. In Selected Topics In The Chemistry Of Natural Products, World Scientific: 2008; pp 1-9.
13. Rashid, A.; Arshad, M. In Medicinal plant diversity, threat imposition and interaction of a mountain people community, Proceeding of Workshop on Curriculum Development in Applied Ethnobotany. Published by the Ethnobotany Project, WWF Pakistan, 2002; pp 84-90.
14. Pine, J.; Pine, B.; Pine, R. M. B., Plants For A Future-Database Search Results.
15. Koyama, J.; Morita, I.; Kobayashi, N.; Hirai, K.; Simamura, E.; Nobukawa, T.; Kadota, S., Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis. Biological and Pharmaceutical Bulletin 2006, 29 (11), 2310-2312.
16. Chattopadhyay, S. K.; Pal, A.; Maulik, P. R.; Kaur, T.; Garg, A.; Khanuja, S. P. S., Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities. Bioorganic & medicinal chemistry letters 2006, 16 (9), 2446-2449.
17. Küpeli, E.; Erdemoğlu, N.; Yeşilada, E.; Şener, B., Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. Journal of ethnopharmacology 2003, 89 (2), 265-270.
18. Nisar, M.; Khan, I.; Ahmad, B.; Ali, I.; Ahmad, W.; Choudhary, M. I., Antifungal and antibacterial activities of Taxus wallichiana Zucc. Journal of enzyme inhibition and medicinal chemistry 2008, 23 (2), 256-260.
19. Muhammad, N.; Saeed, M.; Khan, H. J. B. c.; medicine, a., Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. 2012, 12, 1-8.
20. Muhammad, N.; Saeed, M.; Khan, H.; Adhikari, A.; Khan, K. M. J. J. o. C., Muscle relaxant and sedative-hypnotic activities of extract of Viola betonicifolia in animal models supported by its isolated compound, 4-hydroxy coumarin. 2013, 2013.
21. Abu-Izneid, T.; Rauf, A.; Shah, S. U. A.; Wadood, A.; Abdelhady, M. I. S.; Nathalie, P.; Céline, D.; Mansour, N.; Patel, S., In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species. BioMed Research International 2018, 2018, 3868070.
22. Qayum, M.; Kaleem, W. A.; Rauf, A.; Raza, M.; AlMasoud, N.; S. Alomar, T.; Ahmad, Z.; Sharma, R., In vitro Leishmanicidal evaluation and molecular docking simulations of bioactive compounds from the bark of Taxus wallichiana. Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology 2024, 1-6.
23. Hemeq, Y.; Rauf, A.; Hemeg, H. A.; Akram, Z.; Ahmad, Z.; Naz, H., Anticancer potential of crude extract and Triterpenoid isolated from Datura metel Linnaeus. Journal of Population Therapeutics and Clinical Pharmacology 2023, 30 (19), 1132-1138.
24. Rauf, A.; Wilairatana, P.; Joshi, P. B.; Ahmad, Z.; Olatunde, A.; Hafeez, N.; Hemeg, H. A.; Mubarak, M. S., Revisiting luteolin: An updated review on its anticancer potential. Heliyon 2024.
25. S. AlOmar, T.; Rauf, A.; Rashid, U.; Sarfaraz, S.; Ayub, K.; Hussain, F.; Almasoud, N.; S. AlOmar, A.; Rehman, G.; Ahmad, Z., Molecular docking, DFT studies, and anti-inflammatory evaluation of peshawaraquinone isolated from Fernandoa adenophylla. Journal of Biomolecular Structure and Dynamics 2023, 1-13.
26. Qayum, M.; Nisar, M.; Shah, M. R.; Adhikari, A.; Kaleem, W. A.; Khan, I.; Khan, N.; Gul, F.; Khan, I. A.; Zia‐ul‐Haq, M. J. P. R., Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. 2012, 26 (4), 552-556.
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Published
May 25, 2024
Article Details
How to Cite
Fazli Hadi, Waqar Ahmad Kaleem, Zubair Ahmad, Abdur Rauf, & Naveed Muhammad. (2024). IN VIVO ANALGESIC, MUSCLE RELAXANT AND SEDATIVE EVALUATION OF CRUDE EXTRACT OF TAXUS WALLICIANA Zucc . Journal of Population Therapeutics and Clinical Pharmacology, 31(5), 1833–1838. https://doi.org/10.53555/jptcp.v31i5.6332
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Author Biographies
Fazli Hadi
Department of Pharmacy, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan
Waqar Ahmad Kaleem
Department of Pharmacy, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan
Zubair Ahmad
Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan,
Abdur Rauf
Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan,
Naveed Muhammad
Department of Pharmacy, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan