METHOD DEVELOPMENT AND STABILITY-INDICATING METHOD FOR TALINOLOL EMULSION BY RP-HPLC

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Jasvir Kaur Rahelu
Dr. Sushil Dagadu Patil
Dr.Laxmikant B.Borse

Keywords

Talinolol, Method development, Forced degradation studies, Talinolol emulsions

Abstract

The objective of this investigation was to synthesize Talinolol emulsions at the nanoscale to enhance their release, permeability, and solubility, hence augmenting their oral bioavailability. The development and validation of analytical procedures for the measurement of talinolol in bulk and dose forms were conducted in accordance with the ICH standards. RP-HPLC methods were developed and their specificity, accuracy, precision, and robustness were validated in order to evaluate Talinolol.

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References

1. He Juan, Bernd Terhaag , Yang Li-Ying , Zhang Bi-Kui , Su Fen-Li , Zhu Yun-Gui , Song Juan , Tang Jing , Liu Xiao-Lei , Peng Wen-Xing Determination of talinolol in human plasma by high performance liquid chromatography–electrospray ionization mass spectrometry: Application to pharmacokinetic study Journal of Chromatography B, 2007, 853: 1–2, 15,275-2802.
2. Shriram M Pathak , Prashant B Musmade, Krishnamurthy M Bhat, Nayanabhirama Udupa Validated HPLC method for quantitative determination of talinolol in rat plasma and application to a preclinical pharmacokinetic study .Bioanalysis. 2010,2(1):95-104.
3. V.R. Sinha and Damanjeet Ghai RP-HPLC Stability-Indicating Assay Method for Talinolol and Characterization of its Degradation Products Journal of Chromatographic Science, 2011 Vol. 49, 786-795.
4. Mohsin K , Al-Qahtani S , Alanazi FK Rapid and sensitive bioanalytical stability-indicating method for quantification of talinolol, a selective β1 adrenoceptor antagonist in lipid based formulations using ultrafast UHPLC systems. Acta Poloniae Pharmaceutica, 2014, 71(5):737-745
5. H. Mahgoub, A. Hanafy Development and Validation of a Gradient Elution High-Performance Liquid Chromatographic Method for Determination of Talinolol in Rat Plasma: Application to a Preclinical Food–Drug Interaction Study Acta Chromatographica.2015, 27:1, 67–79.

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Published
Nov 20, 2022
DOI https://doi.org/10.53555/jptcp.v29i5.6319

Article Details

How to Cite
Jasvir Kaur Rahelu, Dr. Sushil Dagadu Patil, & Dr.Laxmikant B.Borse. (2022). METHOD DEVELOPMENT AND STABILITY-INDICATING METHOD FOR TALINOLOL EMULSION BY RP-HPLC. Journal of Population Therapeutics and Clinical Pharmacology, 29(5), 25–31. https://doi.org/10.53555/jptcp.v29i5.6319
Issue
Vol. 29 No. 5 (2022): Special Issue on Multidisciplinary Research
Section
Articles
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Author Biographies

Jasvir Kaur Rahelu

Research Scholar, Sunrise University, Alwar, Rajasthan Research Supervisor, Sunrise University, Alwar, Rajasthan

Dr. Sushil Dagadu Patil

Research Scholar, Sunrise University, Alwar, Rajasthan Research Supervisor, Sunrise University, Alwar, Rajasthan

Dr.Laxmikant B.Borse

Research Co-Supervisor, Sunrise University, Alwar, Rajasthan