CLOTRIMAZOLE ADORNED BETA-CYCLODEXTRIN BASED NANOSPONGES: FABRICATION AND IN-VITRO CHARACTERIZATION

Main Article Content

Farwa Shaheen
Rimsha Liaqat
Hashmat Ullah
Pervaiz Akhtar Shah
Sheikh Abdur Rashid
Syed Atif Raza
Afifa Tariq
Mobina Manzoor
Iqra shahdin
Saima Mahmood
Fazal Rabbi
Wasi Ullah

Keywords

Nanosponges, clotrimazole, beta cyclodextrin-based nanosponges, anti-fungal, physicochemical analysis

Abstract

This research was framed to formulate clotrimazole-loaded beta cyclodextrin-based nanosponges that seemed to be effective for treating fungal infections. Beta-cyclodextrin (rate-retarding polymer), polyvinyl alcohol (surfactant) and dimethylsulfoxide (aprotic solvent) were utilized in different concentrations, to prepare clotrimazole loaded nanosponges through emulsion solvent diffusion technology. Drug loaded nanosponges were evaluated for their physico-chemical parameters. Fourier Transform Infrared spectroscopy and scanning electron microscopy were used for structural analysis. Spherical, spongy, porous and nanosized three-dimensional structures of prepared nanosponges were obtained by SEM. Each formulation's particle size was in nanoscale range. The percentage yield ranged from 77% to 87%. The entrapment efficiency and drug loading were in the range of 80 - 90% and 83 - 85%, respectively, for each formulation. The development of inclusion complexes with porous and spherical morphology was verified by FTIR without any chemical interaction between drug and polymer. These findings reinforced that developed nanosponge formulation serves as an effective nanocarrier, enhancing and regulating the delivery of clotrimazole.

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