Reversible Neurotrophic Keratopathy Associated with Rosuvastatin Therapy: A Case Report

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Ayman Elnahry
Gehad Elnahry


Cranial neuropathy, drug-induced ocular adverse event, neurotrophic keratopathy, rosuvastatin, trigeminal neuropathy


Background and objective:
To report a case of bilateral neurotrophic keratopathy associated with rosuvastatin therapy that dramatically improved following drug discontinuation.
Materials and Methods:
Chart review of the patient’s medical record was performed, and clinical images were analyzed before and after drug discontinuation.
The patient presented with bilateral stage 2 neurotrophic keratopathy with impaired corneal sensation and resistance to conservative ulcer treatment. She had recently started rosuvastatin therapy for hyperlipidemia. Following discontinuation of rosuvastatin therapy, there was dramatic bilateral improvement in corneal sensation, size of the corneal ulcers, and visual acuity.
Rosuvastatin may result in reversible trigeminal nerve impairment and neurotrophic keratopathy.

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