REVERSIBLE NEUROTHROPHIC KERATOPATHY ASSOCIATED WITH ROSUVASTATIN THERAPY A CASE REPORT

Main Article Content

Ayman G. Elnahry
Gehad A. Elnahry

Keywords

cranial neuropathy, drug-induced ocular adverse event, neurotrophic keratopathy, rosuvastatin, trigeminal neuropathy

Abstract


Background
Rosuvastatin is a 3-hydroxy-3-methyl-glutaryl-CoA reductase enzyme inhibitor that is in wide use with few reported ocular adverse events.
Objectives
To report a case of bilateral neurotrophic keratopathy associated with rosuvastatin therapy that dramatically improved following drug discontinuation.
Case presentation
A 65-year-old female presented with painless diminution of vision in both eyes of gradual onset and progressive course for 1 month. She had recently started rosuvastatin therapy for hyperlipidemia. Examination revealed bilateral stage 2 neurotrophic keratopathy with impaired corneal sensation which was previously resistant to conservative ulcer treatment. Following discontinuation of rosuvastatin therapy, there was dramatic bilateral improvement in corneal sensation, size of the corneal ulcers, and visual acuity.
Conclusion
Rosuvastatin may result in reversible trigeminal nerve impairment and neurotrophic keratopathy.
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