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Bashir Ahmed Shaheen
Dr. Ziaur Rahman
Dr. Muhammad Afzal


Hyperresistinemia, Interleukin-6, Insulin resistance, HDL, Diabetes, Central Obesity


Obesity is a multisystem disorder and is strongly associated with metabolic impairments. Obesity is characterized by a state of altered adipose tissue functions with low-grade inflammation, insulin insensitivity and dyslipidemia. The current study aimed to explore the correlation of circulatory resistin with metabolic and inflammatory markers in adults with obesity and healthy lean Pakistani subjects. This study was carried out on 622 Pakistani subjects and anthropometric and clinical parameters were assessed, which include BMI, WHR, blood pressure manually, while resistin, insulin, inflammatory markers by enzyme-linked immunosorbent assay technique (ELISA), and lipids, and glycemic indices using the chemistry analyzer Microlab-300XL.

The analysis revealed that overall circulating resistin was markedly elevated in all categories of obesity as compared to lean, healthy subjects (P<0.001).The resistin outcomes were found to be strongly associated with obesity indices (BMI, r = 0.669 and P<0.001), central adiposity indices (hip, waist, and WHR, r = 0.669 and P<0.001), systolic and diastolic blood pressure (r=0.61, r = 0.625 and P<0.001), HOMA-IR (r = 0.763, and P<0.001), lipid indices (cholesterol with r = 0.759, TGs with r = 0.755 and HDL, r =-0.749 with P< 0.001) and IL-6 with r = 0.849, CRP, r = 0.829 and TNF-α, r =-0.812 with P< 0.001) among lean controls versus metabolically healthy, metabolically unhealthy, and  subjects with obesity and diabetes. The serum resistin level was taken as dependent variable by the reduced model of multiple linear regression presented a highly significant association between elevated resistin and MHO, MUO, and DO (with p<0.001 and all other factors were considered insignificant in this background removal method.

In conclusion the current study uncovered that hyperresistinemia is an important indicator of several health issues, including metabolic dysregulation, insulin resistance, low-grade inflammation, obesity, and type 2 diabetes. These findings underscore the importance of proactive measures to effectively prevent and manage these conditions.

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