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Dr Muthira Mohammad Yaseen
Dr Aasma Naz
Dr Zameer Ahmed
Dr Shazia Ahmed Jatoi
Dr Kiran Aamir
Dr Aamir Ramzan


Pregnant Females, Hepatitis-E, Infection, Knowledge and Perception


Background:  An higher risk of death and terrible consequences is associated with hepatitis E, one of the most prevalent infections that pregnant women face.

 Objective: The aim was to determine how much health education interventions resulted in improving hepatitis E awareness among pregnant women.

 Methods: This cross-sectional study was conducted at Gynae & Obstetric Department PUMHS Civil Hospital Nawabshah from April 2023-September 2023 and comprised of 80 pregnant females. Females with ages 17-45 years were included after taking informed written consent. We used SPSS 22.0 to analyze data. A chi-square test was employed to see whether there was a correlation between the participants' knowledge and perception.

 Results: Pregnant females had mean age 27.9±5.25 years with mean BMI 25.12±7.33 kg/m2. Majority of the females 49 (61.3%) were literate. There were 34 (42.5%) cases had 2nd trimester of pregnancy, followed by 28 (35%) cases had 3rd trimester and 18 (22.5%) cases had first trimester. Among women, 78% had heard of Hepatitis E, 83% had known a person infected via viral infection, 55% didn't know it was caused by a virus, 42% knew it was spread through contaminated water and food, 50% knew it was spread by a blood transfusion, 60% knew it could be spread sexually, 41% knew it could be spread from mother to fetus, and 66% knew it was spread more in pregnancy. Only 40% of women thought that they were at risk of Hepatitis-E.

 Conclusion: Our research shows that pregnant women have a decent understanding of hepatitis E, but that additional health education and immunization campaigns are needed to lower the disease's death toll.

Abstract 66 | PDF Downloads 58


1. World Health Organization. Global Health sector strategy on viral hepatitis 2016-2021: Towards ending viral hepatitis. WHO: 2016.
2. WHO: Global Hepatitis Report: Prevent, test and treat. Accessed on Jul 6, 2018.
3. WHO: Hepatitis E: Key facts. Accessed on June 9, 2018.
4. Dalton HR, Izopet J. Transmission and epidemiology of hepatitis E virus genotype 3 and 4 infections. Cold Spring Harbor Perspect Med. 2018;18(11):a032144.
5. Izopet J, Lhomme S, Chapuy-Regaud S, Mansuy JM, Kamar N, Abravanel F. HEV and transfusion-recipient risk. VHE Risque receveur. 2017;24(3):176–81.
6. Smith DB, Simmonds P. Hepatitis E virus and fulminant hepatitis--a virus or host-specific pathology? Liver Int. 2015;35(4):1334–40.
7. Aggarwal R, Gandhi S. The global prevalence of hepatitis E virus infection and susceptibility: a systematic review. Geneva, Switz: World Health Organization; 2010.
8. Xia H, Wahlberg N, Belák S, Meng XJ, Liu L. The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective. Arch Virol. 2011;156(1):121–4. Epub 2010 Oct 7.
9. Takahashi M, Nishizawa T, Yoshikawa A, Sato S, Isoda N, Ido K, et al. Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J Gen Virol. 2002;83(Pt 8):1931–40.
10. Ciglenecki I, Rumunu J, Wamala JF, Nkemenang P, Duncker J, Nesbitt R, et al. The first reactive vaccination campaign against hepatitis E. Lancet Infect Dis [Internet]. 2022;22(8):1110–1.
11. Moin A, Fatima H, Qadir TF. Tackling hepatitis C—Pakistan’s road to success. Lancet [Internet]. 2018;391(10123):834–5.
12. Sultana R, Humayun S, Manzoor S, Humayun S. Research Article. 2022;4–9.
13. Teo CG. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol Infect. 2012;140(5):767–87. Epub 2012 Jan 25.
14. Fiore S, Savasi V. Treatment of viral hepatitis in pregnancy. Expert Opin Pharmacother. 2009;10(17):2801–9.
15. Navaneethan U, Al Mohajer M, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int. 2008;28(9):1190–9. Epub 2008 Jul 25.
16. Farooqi MA, Ahsan A, Yousuf S, Shakoor N, Muhammad H, Farooqi U. Seroprevalence of Hepatitis E Virus Antibodies (IgG) in the Community of Rawalpindi. 2022;108–15.
17. Pawlotsky JM, Negro F, Aghemo A, Berenguer M, Dalgard O, Dusheiko G, et al. EASL Recommendations on Treatmefile:///C:/Users/DR JIBRAN UMAR AYUB/Desktop/ref.pdfnt of Hepatitis C 2018.
18. Chan HLY, Wong GLH, Wong VWS, Wong MCS, Chan CYK, Singh S. Questionnaire survey on knowledge, attitudes, and behaviour towards viral hepatitis among the Hong Kong public. Hong Kong Med J. 2022;28(1):45–53.
19. Rein DB, Stevens GA, Theaker J, Wittenborn JS, Wiersma ST. The global burden of hepatitis E virus genotypes 1 and 2 in. Hepatology (Baltimore, Md) 2012. 2005;55(4):988–97.
20. Lata I. Hepatobiliary diseases during pregnancy and their management: an update. Int J Crit Illness Inj Sci. 2013;3(3):175–82