Potential Neuroprotective Effect of Trimetazidine and Metformin on Autophagy in a Rat Model of Diabetic Peripheral Neuropathy: Role of LC3 and P62
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Keywords
Trimetazidine; metformin; autophagy; diabetic peripheral neuropathy
Abstract
Diabetic peripheral neuropathy (DPN), a common complication of diabetes
mellitus. Currently, no specific etiology treatment has been established promoting a keen
investigation into the underlying mechanism and potential strategies in the medical field. This
study tested the potential protective effect of trimetazidine or metformin each of them alone
or combined on autophagy in a rat model of diabetic peripheral neuropathy
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