A NARRATIVE REVIEW ON SALIVARY METABOLOMES AND DIETARY INTERVENTIONS IN AUTISM SPECTRUM DISORDER
Main Article Content
Keywords
Autism spectrum disorders, Biomarkers, Saliva, Children, Metabolomics, Dietary Intervention
Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental disorders with around 1% prevalence in children, posing challenges for early diagnosis and treatment. Genetic and environmental factors play crucial roles in ASD etiology. Identifying body fluid metabolome and proteome profiles has revealed metabolic anomalies in patients, offering potential ASD biomarkers. Currently, no definitive therapy exists, and conflicting information surrounds alternative treatments. Addressing abnormal metabolites related to oxidative stress, dietary modification to some extent may partially reverse autism. Dietary intervention helps in some cases but represents a small segment due to ASD's wide spectrum. Understanding ASD's pathophysiology becomes increasingly vital with rising patient numbers. Metabolomics biomarkers, especially salivary metabolomic changes, hold promise for early autism diagnosis.
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Jan 10, 2023
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Renu Singh, Alka Shah, Nayan Jain, Harshuti Shah, Akanksha Trivedi, Ravidarshdeep Kaur, & Rakesh Rawal. (2023). A NARRATIVE REVIEW ON SALIVARY METABOLOMES AND DIETARY INTERVENTIONS IN AUTISM SPECTRUM DISORDER. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 2857-2871. https://doi.org/10.53555/jptcp.v31i1.6078
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Author Biographies
Renu Singh
Department of Life Science, Food Science, and Nutrition, Gujarat University, Ahmedabad-380009
Alka Shah
Department of Life Science, Food Science, and Nutrition, Gujarat University, Ahmedabad-380009
Nayan Jain
Department of Life Science, Food Science, and Nutrition, Gujarat University, Ahmedabad-380009
Harshuti Shah
Rajvee Ortho, Spine & Child Neuro Hospital, Ahmedabad-380009 Rakesh M Rawal (ORCID: 0000-0002-7985-1187)
Akanksha Trivedi
Advait Theragnostic, Ahmedabad-380009
Ravidarshdeep Kaur
Department of Biochemistry and Forensic Science, Gujarat University, Ahmedabad-380009
Rakesh Rawal
Department of Biochemistry and Forensic Science, Gujarat University, Ahmedabad-380009
How to Cite
Renu Singh, Alka Shah, Nayan Jain, Harshuti Shah, Akanksha Trivedi, Ravidarshdeep Kaur, & Rakesh Rawal. (2023). A NARRATIVE REVIEW ON SALIVARY METABOLOMES AND DIETARY INTERVENTIONS IN AUTISM SPECTRUM DISORDER. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 2857-2871. https://doi.org/10.53555/jptcp.v31i1.6078