THE IMPACT OF OBESITY ON SERUM ALBUMIN LEVELS IN ADULTS WITHOUT LIVER OR KIDNEY DYSFUNCTION

Main Article Content

Dr Neha Shehzad
Dr Syed Sebghatullah
Dr Jai Chand
Dr Moazama Shakeel Ahmed
Dr Yamna Fatima
Dr Rida Masood

Keywords

Obesity, body mass index(BMI), albumin, hypoalbuminemia

Abstract

Aim/Objective:


To investigate the relation of obesity and low albumin levels in individuals devoid of liver or kidney disease manifestations.


Materials and methods:


This cross-sectional descriptive study, conducted at King Edward Medical University/ Mayo Hospital Lahore sought to evaluate the link between obesity and hypoalbuminemia. A cohort of 138 patients, ranging in age from eighteen to seventy years with no evidence of liver and kidney disease, were recruited. Participants were divided into three categories determined by BMI: normal-weight controls, obese, and severely obese. Demographic data such as height, weight, and genders were obtained, as well as details about type 2 diabetes, ongoing medical conditions, and medication history. Albumin levels were measured in venous blood samples, and statistical analysis was carried out using SPSS version 23.0. Descriptive statistics were calculated to determine the correlation between obesity and hypoalbuminemia (p < 0.05).


Results:


In a study of 138 participants, there was no significant difference in mean age between normal control, obese, and morbidly obese groups: 39.4 ± 15.5 years for normal-weight controls, 43.6 ± 14.5 years for obese, and 47.9 ± 14.9 years for severely obese (p = 0.105). The male versus female pattern was identical: 54.3% in healthy subjects, 35.5% in obese, and 42.8% in severely obese (p = 0.193). Diabetes mellitus was prevalent in 24.6% of healthy controls, 44.2% of the obese, and 51.4% of the severely obese (p = 0.059). Hypoalbuminemia prevalence was 8.7% in normal-weight subjects, 37.0% in the obese, and 43.5% in the severely obese, with a significant difference noted (p = 0.002). Median albumin levels were 4.0 (3.6 - 4.2) g/dL in healthy controls, 3.7 (3.2 - 3.9) g/dL in the obese, and 3.5 (3.2 - 3.7) g/dL in the morbidly obese, indicating a statistically significant variation (p < 0.001).


Conclusion:


The study accentuates the significant link between obesity and hypoalbuminemia. Clear guidelines are crucial for interpreting serum-albumin statistics in obese people. The notable prevalence of hypoalbuminemia in obese individuals, emphasize its importance as an independent prognostic factor. International consensus is needed to optimize obesity management and enhance nutrition care.

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