LIVER ENZYMES IN TYPE-2 DIABETES MELLITUS PATIENTS
Main Article Content
Keywords
Glucose, ALT, AST, GGT, Total protein, Albumin, Total bilirubin, Conjugated bilirubin
Abstract
Background: Diabetes is a strong-growing metabolic ailment across the globe. The occurrence of
diabetes everywhere the world affects more than 8% of the global population. "Type 2 diabetes (T2D) is
Liver Enzymes In Type-2 Diabetes Mellitus Patients
Vol.31 No.04 (2024): JPTCP (1125-1132) Page | 1126
a major public health concern distressing lots of people globally." "Nearly 70% of patients with type 2
diabetes mellitus (T2DM) have a fatty liver."
Aims and objectives: We aimed to detect the rise of liver enzymes and its association with Type-2
diabetes mellitus associated with liver dysfunction. The aim of the study was to measure the level of liver
enzymes.
Material and methods: A case-control type of study was enrolled total of 60 age sex matched
subjects, where subject were further categories into 30 type-II diabetic mellitus attending
Endocrinology outpatient of Sri Venkateswara Institute of Medical Sciences, Tirupati and 30
healthy individuals of in and around of institution. A confirm diagnosis of type-II DM was based on
standard ADA criteria. Statistical analysis was done by using SPPS version 16.
Results: A total of 60 subjects were assessed for liver profile and diabetic profiles. A data was
presented in mean and SD form. The mean age of participants was 46.77 ± 7.74. Blood sugar levels
(fasting & PP2) and liver enzymes were significantly increased, while mean levels of protein fractions
were significantly decreases in cases as compared to controls (p<0.005)
Conclusion: Biomarkers will play a crucial role in early suspicion, diagnosis, monitoring, and
recognition of complications, management, and disposition of patients. Each of these components in
turn can have crucial implications on the healthcare system and the administrative machinery, directly
impacting patient care
References
2. Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity onset diabetes of the young. N Engl J Med 2001;345:971-80.
3. King H, Aubert RE, Herman WH. Global burden of diabetes 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-31.
4. Kaplan LA, Pesce JA. Clinical chemistry Analysis, correlation 5 th edition. Missouri. Mousby: Elsevier;2010. p.586-87.
5. American Diabetes Association. Standards of Medical Care in Diabetes 2014. Diabetes Care 2014: 37: S14-S80.
6. Vasudevan DM and Sreekumari S. Textbook of Biochemistry for medical students. Jaypee Brothers Medical Publishers (P) LTD, New Delhi; 2011.Regulation of Blood Glucose Insulin and Diabetes Mellitus; p.266-78.
7. Elmahi HM, Abd Elkaram A, Abdrabo. Determinants of abnormal liver function tests in diabetes type 2 patients in Sudan. Journal of science 2014;4:45-49
8. Reaven GM. Banting lecture: role of insulin resistance in human disease. Diabetes 1988;37(12):1595–607.
9. Funahashi T, Nakamura T, Shimomura I, Maeda K, Kuriyama.H, Takahashi M, et al. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med. 1999 Feb;38(2):202-6.
10. Idris AS, Hammad Mekkay KF, Abdalla BEE and Ali KA. Liver function tests in type 2 Sudanese diabetic patients. Int J Nutr Metab. 2011;3:17–21.
11. Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of Liver Disease in Type 2 Diabetes and Management of Patients With Diabetes and Liver Disease. Diabetes care;2007; 30(3):734-743.
12. West J, Brousil J, Gazis A, Jackson L, Mansell P, Bennett A, et al. Elevated serum alanine transaminase levels in patients with type 1 or type 2 diabetes mellitus.QJM 2006 ;99(12):871-6.
13. Takhelmayum R, Thanpari C and s Singh P : Liver dysfunction in diabetic patients admitted in referral hospital . Bali Medical Journal 2014 . Diabetes care 1984 ;7:248-54.
14. Iqbal A, Iftikar U, AF Ali, Shakoor M, Zuberi N. Comparison of gamma glutamyl transferase in normal and type 2 diabetic patients. J Pak Med Assoc 2010;60: 945-948.
15. Harris EH. Elevated Liver Function Tests In Type 2 Diabetes. Clin Diab. 2005;23:115–119.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Pradeep Kumar Burubu
Tutor and Research Scholar, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India
Ivvala Anand Shaker
Professor and Head, Department of Biochemistry, Swaminarayan Institute of Medical Sciences and Research, Swaminarayan University, Ahmedabad- Gujarat, India.
Pawan Anilkumar Toshniwal
Associate Professor, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India
Seema Toshniwal
Tutor, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India.
M.M. Suchitra
Professor, Dept of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
V.S. Kiranmayi
Associate Professor, Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Brahma Reddy Malapati
Associate Professor, Department of Biochemistry, MK Shah Medical College, Ahmadabad Gujarat, India
Bidwe Santosh Eknath
Assistant Professor, Department of Biochemistry, Government Medical College, Alibag, Raigad, Maharashtra
Dussa Hemachandan
Assistant Professor and Research Scholar, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India
Lewin Wilson C
Tutor, Department of Biochemistry, SRM Medical College, Kattankulathur, Chennai, Tamil Nadu, India
Barla Krishna
Tutor, Department of Biochemistry, Gayatri Vidya Parishad Institute of Health Care and Medical Technology. Visakhapatnam, Andhra Pradesh, India
Aafrin Daruwala
Tutor and Research Scholar, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India.
Twinkal Varsani
Resident, Department of Biochemistry, Parul Institute of Medical Sciences & Research, Parul University, Vadodara, Gujarat, India.