INTERACTIONS OF WARFARIN WITH DRUGS AND FOOD
Main Article Content
Keywords
Warfarin, anticoagulant, drug interactions, food interactions, therapeutic
Abstract
Warfarin is a commonly used anticoagulant medication that is prescribed to patients at risk of developing blood clots. However, warfarin has a narrow therapeutic index, meaning that small changes in its concentration can lead to serious side effects, such as bleeding or an increased risk of stroke. Therefore, it is essential for healthcare providers and patients to be aware of potential interactions between warfarin and other drugs or foods that can affect its effectiveness.
References
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10. Li, S., Liu, S., Yang, Y., & Li, W. (2020). Characterization of warfarin inhibition kinetics requires stabilization of intramembrane vitamin K epoxide reductases. Journal of molecular biology. nih.gov
11. Gómez-Garduño, J., León-Rodríguez, R., Alemón-Medina, R., Pérez-Guillé, B. E., Soriano-Rosales, R. E., González-Ortiz, A., ... & Rivera-Espinosa, L. (2022). Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals. Dose-Response, 20(3), 15593258221120485. sagepub.com
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13. Huybrechts, K. F., Gopalakrishnan, C., Bartels, D. B., Zint, K., Gurusamy, V. K., Landon, J., & Schneeweiss, S. (2020). Safety and effectiveness of dabigatran and other direct oral anticoagulants compared with warfarin in patients with atrial fibrillation. Clinical Pharmacology & Therapeutics, 107(6), 1405-1419. researchgate.net
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15. Någård, M., Kramer, W. G., & Boulton, D. W. (2021). Evaluation of potential drug interactions with sodium zirconium cyclosilicate: a single-center, open-label, one sequence crossover study in healthy adults. Clinical Kidney Journal. oup.com
16. Rydberg, D. M., Linder, M., Malmström, R. E., & Andersen, M. (2020). Risk factors for severe bleeding events during warfarin treatment: the influence of sex, age, comorbidity and co-medication. European journal of clinical pharmacology, 76, 867-876. springer.com
2. Nagaraj, T. A., Snider, M. J., Davidson, E., Weiss, R., Li, J., & Afzal, M. (2021). Risk versus benefit of combined aspirin and warfarin therapy in patients with atrial fibrillation. Journal of Pharmacy Practice, 34(5), 766-773. [HTML]
3. Holm, J., Mannheimer, B., Malmström, R. E., Eliasson, E., & Lindh, J. D. (2021). Bleeding and thromboembolism due to drug-drug interactions with non-vitamin K antagonist oral anticoagulants—a Swedish, register-based cohort study in atrial fibrillation outpatients. European journal of clinical pharmacology, 77, 409-419. springer.com
4. Zapata, L. V., Hansten, P. D., Panic, J., Horn, J. R., Boyce, R. D., Gephart, S., ... & Malone, D. C. (2020). Risk of bleeding with exposure to warfarin and nonsteroidal anti-inflammatory drugs: a systematic review and meta-analysis. Thrombosis and haemostasis, 120(07), 1066-1074. nih.gov
5. Wang, M., Zeraatkar, D., Obeda, M., Lee, M., Garcia, C., Nguyen, L., ... & Holbrook, A. (2021). Drug–drug interactions with warfarin: A systematic review and meta‐analysis. British journal of clinical pharmacology, 87(11), 4051-4100. wiley.com
6. Spina, E., Barbieri, M. A., Cicala, G., Bruno, A., & de Leon, J. (2020). Clinically relevant drug interactions between newer antidepressants and oral anticoagulants. Expert opinion on drug metabolism & toxicology, 16(1), 31-44. [HTML]
7. Adams, D. R., & Rahn, A. R. (2023). Antibiotic Prophylaxis in Oral and Maxillofacial Surgery: Recent Trends. Oral and Maxillofacial Surgery, Medicine, and Pathology for the Clinician, 283. [HTML]
8. Putriana, N. A., Rusdiana, T., Rostinawati, T., & Akbar, M. R. (2022). Influence of Vitamin K intake on INR and Anticoagulation in outpatients taking Warfarin. Research Journal of Pharmacy and Technology, 15(10), 4851-4856. rjptonline.org
9. Liu, S., Li, S., Shen, G., Sukumar, N., Krezel, A. M., & Li, W. (2021). Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Science. nih.gov
10. Li, S., Liu, S., Yang, Y., & Li, W. (2020). Characterization of warfarin inhibition kinetics requires stabilization of intramembrane vitamin K epoxide reductases. Journal of molecular biology. nih.gov
11. Gómez-Garduño, J., León-Rodríguez, R., Alemón-Medina, R., Pérez-Guillé, B. E., Soriano-Rosales, R. E., González-Ortiz, A., ... & Rivera-Espinosa, L. (2022). Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals. Dose-Response, 20(3), 15593258221120485. sagepub.com
12. Rodriguez Lago, M. (2022). Assessment of Alcohol Consumption in Outpatients with Non-alcoholic Fatty Liver Disease. uni-hamburg.de
13. Huybrechts, K. F., Gopalakrishnan, C., Bartels, D. B., Zint, K., Gurusamy, V. K., Landon, J., & Schneeweiss, S. (2020). Safety and effectiveness of dabigatran and other direct oral anticoagulants compared with warfarin in patients with atrial fibrillation. Clinical Pharmacology & Therapeutics, 107(6), 1405-1419. researchgate.net
14. Mar, P. L., Gopinathannair, R., Gengler, B. E., Chung, M. K., Perez, A., Dukes, J., ... & from the American Heart Association Electrocardiography & Arrhythmias Committee of the Council of Clinical Cardiology. (2022). Drug interactions affecting oral anticoagulant use. Circulation: Arrhythmia and Electrophysiology, 15(6), e007956. ahajournals.org
15. Någård, M., Kramer, W. G., & Boulton, D. W. (2021). Evaluation of potential drug interactions with sodium zirconium cyclosilicate: a single-center, open-label, one sequence crossover study in healthy adults. Clinical Kidney Journal. oup.com
16. Rydberg, D. M., Linder, M., Malmström, R. E., & Andersen, M. (2020). Risk factors for severe bleeding events during warfarin treatment: the influence of sex, age, comorbidity and co-medication. European journal of clinical pharmacology, 76, 867-876. springer.com
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Published
Oct 27, 2022
Article Details
How to Cite
Osama Mohammed Alzahrani, Ghadi Abulraheem Tayeb, Eman Hussain Belal, Thamer Ghazi Al-Johani, Mohammed Ahmed alqarni, & Mohammed Ahmed Jaber Alshehri. (2022). INTERACTIONS OF WARFARIN WITH DRUGS AND FOOD. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 2831–2838. https://doi.org/10.53555/jptcp.v29i04.5662
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Author Biographies
Osama Mohammed Alzahrani
Pharmacist, Alnoor Specialist Hospital in Makkah
Ghadi Abulraheem Tayeb
Pharmacist, Alnoor Specialist Hospital in Makkah
Eman Hussain Belal
Pharmacy technician, King Fahad General Hospital in Jeddah
Thamer Ghazi Al-Johani
Pharmacy technician, King Fahad General Hospital in Jeddah
Mohammed Ahmed alqarni
Pharmacy technician, Eradah and mental health complex-Eradah service.
Mohammed Ahmed Jaber Alshehri
Pharmacy technician, King Khalid Hospital in Al Kharj