PREGNANCY ASSOCIATED BREAST CANCER (PABC): REPORT FROM A PERIPHERAL PRIMARY SUB CENTRE IN NORTH EAST INDIA
Main Article Content
Keywords
Pregnancy associated Breast cancer(PABC), triple negative breast cancer (TNBC), hormone receptor (HR), HER 2, Invasive ductal carcinoma(IDC), Early Breast Cancer (EBC), Locally Advanced Breast Cancer (LABC), MBC- Metastatic Breast Cancer, Antepartum, Postpartum, MTP – Medical Termination of Pregnancy, FTD, NACT- Neo Adjuvant Chemo Therapy, BCS- Breast Conserving Surgery, MRM – Modified Radical Mastectomy
Abstract
Background
Pregnancy associated breast cancer (PABC) is a rare entity and defined as breast cancer diagnosed during pregnancy or one-year post-partum. There is sparse data especially from low and middle-income countries (LMIC) and merits exploration.
Methods
The study (2015 to 2020) evaluated clinicopathological characteristics, treatment patterns and outcomes of PABC.
Results
There were 10 patients, median age of 29.5 years; 4 had triple-negative disease, 3 had hormone-receptor (HR) positive and HER2 negative, 2 had HER2-positive and HR negative and 1 had triple positive disease. 8 had IDC grade III tumour’s and 6 had delayed diagnosis. 2 patients were EBC, 6 patients were LABC and 2 patients were MBC. Trastuzumab, tamoxifen, and radiotherapy were administered post-delivery.
Of the 10 patients, 7 were diagnosed antepartum (AP) and 3 had termination, 1 had preterm and 3 had full-term deliveries(FTDs). Among 3 patients who underwent MTP 2 patients had metastatic disease and 1 patients underwent termination willingly. Among postpartum group (n= 3), all were LABC and underwent NACT.
Conclusion
Data from the tertiary cancer centre in North east India showed that the majority had delayed diagnosis and aggressive features(TNBC, higher grade). Treatment was feasible in majority and with favourable maternal and foetal outcomes.
References
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr Siddhartha Buragoha
Assistant Professor, Department of Obstetrics and Gynaecology, Silchar Medical College and Hospital, Silchar, Assam, India.
Dr. Pompi Daimari
Consultant, Breast Oncosurgeon, Jorhat Christian Mission centre, Assam, India.